Nature Communications (Oct 2019)
Pparg promotes differentiation and regulates mitochondrial gene expression in bladder epithelial cells
- Chang Liu,
- Tiffany Tate,
- Ekatherina Batourina,
- Steven T. Truschel,
- Steven Potter,
- Mike Adam,
- Tina Xiang,
- Martin Picard,
- Maia Reiley,
- Kerry Schneider,
- Manuel Tamargo,
- Chao Lu,
- Xiao Chen,
- Jing He,
- Hyunwoo Kim,
- Cathy Lee Mendelsohn
Affiliations
- Chang Liu
- Department of Urology, Genetics, and Devlopment, Pathology and Cell Biology and CSCI, Columbia University
- Tiffany Tate
- Department of Urology, Genetics, and Devlopment, Pathology and Cell Biology and CSCI, Columbia University
- Ekatherina Batourina
- Department of Urology, Genetics, and Devlopment, Pathology and Cell Biology and CSCI, Columbia University
- Steven T. Truschel
- Department of Cell Biology, University of Pittsburgh School of Medicine
- Steven Potter
- Division of Developmental Biology, Cincinnati Children’s Medical Center
- Mike Adam
- Division of Developmental Biology, Cincinnati Children’s Medical Center
- Tina Xiang
- Department of Urology, Genetics, and Devlopment, Pathology and Cell Biology and CSCI, Columbia University
- Martin Picard
- Department of Psychiatry and Neurology, Columbia University
- Maia Reiley
- Department of Urology, Genetics, and Devlopment, Pathology and Cell Biology and CSCI, Columbia University
- Kerry Schneider
- Department of Urology, Genetics, and Devlopment, Pathology and Cell Biology and CSCI, Columbia University
- Manuel Tamargo
- Department of Urology, Genetics, and Devlopment, Pathology and Cell Biology and CSCI, Columbia University
- Chao Lu
- Department of Genetics and Development, Columbia University
- Xiao Chen
- Department of Genetics and Development, Columbia University
- Jing He
- Department of Systems Biology, Columbia University
- Hyunwoo Kim
- Department of Urology, Genetics, and Devlopment, Pathology and Cell Biology and CSCI, Columbia University
- Cathy Lee Mendelsohn
- Department of Urology, Genetics, and Devlopment, Pathology and Cell Biology and CSCI, Columbia University
- DOI
- https://doi.org/10.1038/s41467-019-12332-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
The nuclear receptor Pparg regulates urothelial differentiation in vitro but its role in healthy urothelium is unclear. Here, the authors show that PPAR gamma mediates urothelial development during both homeostasis (via mitochondrial function) and following infection, via an inflammatory response.
