Nature Communications (Mar 2022)
Spinal cord injury impairs cardiac function due to impaired bulbospinal sympathetic control
- Mary P. M. Fossey,
- Shane J. T. Balthazaar,
- Jordan W. Squair,
- Alexandra M. Williams,
- Malihe-Sadat Poormasjedi-Meibod,
- Tom E. Nightingale,
- Erin Erskine,
- Brian Hayes,
- Mehdi Ahmadian,
- Garett S. Jackson,
- Diana V. Hunter,
- Katharine D. Currie,
- Teresa S. M. Tsang,
- Matthias Walter,
- Jonathan P. Little,
- Matt S. Ramer,
- Andrei V. Krassioukov,
- Christopher R. West
Affiliations
- Mary P. M. Fossey
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Shane J. T. Balthazaar
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Jordan W. Squair
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Alexandra M. Williams
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Malihe-Sadat Poormasjedi-Meibod
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Tom E. Nightingale
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Erin Erskine
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Brian Hayes
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Mehdi Ahmadian
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Garett S. Jackson
- Faculty of Health and Social Development, University of British Columbia
- Diana V. Hunter
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Katharine D. Currie
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Teresa S. M. Tsang
- Division of Cardiology, University of British Columbia, Vancouver General and University of British Columbia Hospital Echocardiography Department
- Matthias Walter
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Jonathan P. Little
- School of Health and Exercise Sciences, University of British Columbia
- Matt S. Ramer
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Andrei V. Krassioukov
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- Christopher R. West
- International Collaboration on Repair Discoveries (ICORD), University of British Columbia
- DOI
- https://doi.org/10.1038/s41467-022-29066-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
By combining experimental models with prospective clinical studies, the authors show that spinal cord injury causes a rapid reduction in cardiac function that precedes structural changes, and that the loss of descending sympathetic control is the major cause of reduced cardiac function following spinal cord injury.
