Genetic research as a method for assessing susceptibility to prostate cancer

Abstract

The article presents the analyzes of literature sources describing the relationship between pathological alleles of some genes and prostate cancer, which can be used to determine the risk of developing prostate cancer. Mutations of the genes such as HOXB13 (251G/A, G84E), BRCA1 (5382insC, 185delAG, 4153delA, 3819delGTAAA, 3875delGTCT, 300T/G,2080delA) and BRCA2,CHEK2 (1100delC, I157T), ELAC2 (Leu217, Thr541, 650T, 1618a), cdh1 gene (160C/a), AR gene (CAG trinucleotide repeats), VDR gene (rs1544410, rs10875692, rs7301552, rs7975232, rs731236), GST family genes (null alleles of GSTM1 and GSTT1, single-nucleotide substitutions of GSTP1 313a/G and 341c/T), as well as Bloom's syndrome genes were studied. We described what mutations have a proven statistical association with an increased risk of prostate cancer. At the same time, the correlation between the patient's ethnicity and an increased risk of prostate cancer, when there are mutations of BRCA1, AR, VDR and GST family genes, is also noted.

Keywords

• prostate cancer
• genetic research
• gene-mutations