Nature Communications (May 2020)
Using apelin-based synthetic Notch receptors to detect angiogenesis and treat solid tumors
- Zhifu Wang,
- Fan Wang,
- Junjie Zhong,
- Tongming Zhu,
- Yongtao Zheng,
- Tong Zhao,
- Qiang Xie,
- Fukai Ma,
- Ronggang Li,
- Qisheng Tang,
- Feng Xu,
- Xueying Tian,
- Jianhong Zhu
Affiliations
- Zhifu Wang
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Fan Wang
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Junjie Zhong
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Tongming Zhu
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Yongtao Zheng
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Tong Zhao
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Qiang Xie
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Fukai Ma
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Ronggang Li
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Qisheng Tang
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Feng Xu
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- Xueying Tian
- Key Laboratory of Regenerative Medicine of Ministry of Education, College of Life Science and Technology, Jinan University
- Jianhong Zhu
- Department of Neurosurgery, Fudan University Huashan Hospital, Institute of Brain Science, State Key laboratory of Medical Neurobiology, Shanghai Key Laboratory of Brain Function and Regeneration, Shanghai Medical College, Fudan University
- DOI
- https://doi.org/10.1038/s41467-020-15729-4
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Cellular markers of endothelial cell proliferation help identify the vasculature of tumours in homeostasis. Here, the authors report Apelin-based synthetic Notch (synNotch) receptors that can target Apj expressed on endothelium and stimulate the synNotch pathways upon Apj binding, and suggest this as a strategy to treat solid tumours.
