First data on Pneumocystis jirovecii colonization in patients with respiratory diseases in North Lebanon

S. Khalife; E.M. Aliouat; C.M. Aliouat-Denis; N. Gantois; P. Devos; H. Mallat; E. Dei-Cas; F. Dabboussi; M. Hamze; E. Fréalle

doi:10.1016/j.nmni.2015.02.006

New Microbes and New Infections (Jul 2015)

First data on Pneumocystis jirovecii colonization in patients with respiratory diseases in North Lebanon

S. Khalife,
E.M. Aliouat,
C.M. Aliouat-Denis,
N. Gantois,
P. Devos,
H. Mallat,
E. Dei-Cas,
F. Dabboussi,
M. Hamze,
E. Fréalle

Affiliations

S. Khalife: Biology and Diversity of Emerging Eukaryotic Pathogens (BDPEE), Pasteur Institute of Lille, Centre for Infection and Immunity of Lille, University of Lille, Lille, France
E.M. Aliouat: Biology and Diversity of Emerging Eukaryotic Pathogens (BDPEE), Pasteur Institute of Lille, Centre for Infection and Immunity of Lille, University of Lille, Lille, France
C.M. Aliouat-Denis: Biology and Diversity of Emerging Eukaryotic Pathogens (BDPEE), Pasteur Institute of Lille, Centre for Infection and Immunity of Lille, University of Lille, Lille, France
N. Gantois: Biology and Diversity of Emerging Eukaryotic Pathogens (BDPEE), Pasteur Institute of Lille, Centre for Infection and Immunity of Lille, University of Lille, Lille, France
P. Devos: Department of Research, Lille University Hospital, Lille, France
H. Mallat: Health and Environment Microbiology Laboratory, AZM Centre for Research in Biotechnology and its Application, Doctoral School of Sciences and Technology, Lebanese University, Tripoli, Lebanon
E. Dei-Cas: Biology and Diversity of Emerging Eukaryotic Pathogens (BDPEE), Pasteur Institute of Lille, Centre for Infection and Immunity of Lille, University of Lille, Lille, France
F. Dabboussi: Health and Environment Microbiology Laboratory, AZM Centre for Research in Biotechnology and its Application, Doctoral School of Sciences and Technology, Lebanese University, Tripoli, Lebanon
M. Hamze: Health and Environment Microbiology Laboratory, AZM Centre for Research in Biotechnology and its Application, Doctoral School of Sciences and Technology, Lebanese University, Tripoli, Lebanon
E. Fréalle: Biology and Diversity of Emerging Eukaryotic Pathogens (BDPEE), Pasteur Institute of Lille, Centre for Infection and Immunity of Lille, University of Lille, Lille, France

DOI: https://doi.org/10.1016/j.nmni.2015.02.006
Journal volume & issue: Vol. 6, no. C
pp. 11 – 14

Abstract

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Pneumocystis colonization may play a role in transmission and local inflammatory response. It was explored in patients with respiratory diseases in North Lebanon. Overall prevalence reached only 5.2% (95% CI 2.13–10.47) but it was higher (17.3%) in the subpopulation of patients with chronic obstructive pulmonary disease (COPD). COPD was the only factor associated with a significantly increased risk of colonization. mtLSU genotyping revealed predominance of genotype 2, identified in five patients (71.4%), including one patient who had co-infection with genotype 3. These first data in North Lebanon confirm Pneumocystis circulation among patients with respiratory diseases and the potential for transmission to immunocompromised patients.

Published in New Microbes and New Infections

ISSN: 2052-2975 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Infectious and parasitic diseases
Website: https://www.sciencedirect.com/journal/new-microbes-and-new-infections

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