Frontiers in Microbiology (Sep 2022)
Comprehensive phylogeographic and phylodynamic analyses of global Senecavirus A
- Han Gao,
- Han Gao,
- Han Gao,
- Han Gao,
- Yong-jie Chen,
- Yong-jie Chen,
- Yong-jie Chen,
- Yong-jie Chen,
- Xiu-qiong Xu,
- Zhi-ying Xu,
- Zhi-ying Xu,
- Zhi-ying Xu,
- Zhi-ying Xu,
- Si-jia Xu,
- Si-jia Xu,
- Si-jia Xu,
- Si-jia Xu,
- Jia-bao Xing,
- Jia-bao Xing,
- Jia-bao Xing,
- Jia-bao Xing,
- Jing Liu,
- Jing Liu,
- Jing Liu,
- Jing Liu,
- Yun-feng Zha,
- Yan-kuo Sun,
- Yan-kuo Sun,
- Yan-kuo Sun,
- Yan-kuo Sun,
- Gui-hong Zhang,
- Gui-hong Zhang,
- Gui-hong Zhang,
- Gui-hong Zhang
Affiliations
- Han Gao
- Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Han Gao
- Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China
- Han Gao
- Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China
- Han Gao
- National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China
- Yong-jie Chen
- Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Yong-jie Chen
- Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China
- Yong-jie Chen
- Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China
- Yong-jie Chen
- National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China
- Xiu-qiong Xu
- Guangdong Animal Health and Quarantine Office, Guangdong Animal Disease Prevention and Control Center, Guangzhou, China
- Zhi-ying Xu
- Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Zhi-ying Xu
- Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China
- Zhi-ying Xu
- Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China
- Zhi-ying Xu
- National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China
- Si-jia Xu
- Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Si-jia Xu
- Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China
- Si-jia Xu
- Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China
- Si-jia Xu
- National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China
- Jia-bao Xing
- Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Jia-bao Xing
- Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China
- Jia-bao Xing
- Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China
- Jia-bao Xing
- National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China
- Jing Liu
- Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Jing Liu
- Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China
- Jing Liu
- Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China
- Jing Liu
- National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China
- Yun-feng Zha
- Guangdong Animal Health and Quarantine Office, Guangdong Animal Disease Prevention and Control Center, Guangzhou, China
- Yan-kuo Sun
- Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Yan-kuo Sun
- Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China
- Yan-kuo Sun
- Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China
- Yan-kuo Sun
- National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China
- Gui-hong Zhang
- Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Gui-hong Zhang
- Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China
- Gui-hong Zhang
- Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China
- Gui-hong Zhang
- National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou, China
- DOI
- https://doi.org/10.3389/fmicb.2022.980862
- Journal volume & issue
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Vol. 13
Abstract
Senecavirus A (SVA) is a member of the genus Senecavirus in the family Picornaviridae that infects pigs and shows symptoms similar to foot and mouth diseases and other vesicular diseases. It is difficult to prevent, thus, causing tremendous economic loss to the pig industry. However, the global transmission routes of SVA and its natural origins remain unclear. In this study, we processed representative SVA sequences from the GenBank database along with 10 newly isolated SVA strains from the field samples collected from our lab to explore the origins, population characteristics, and transmission patterns of SVA. The SVA strains were firstly systematically divided into eight clades including Clade I–VII and Clade Ancestor based on the maximum likelihood phylogenetic inference. Phylogeographic and phylodynamics analysis within the Bayesian statistical framework revealed that SVA originated in the United States in the 1980s and afterward spread to different countries and regions. Our analysis of viral transmission routes also revealed its historical spread from the United States and the risk of the global virus prevalence. Overall, our study provided a comprehensive assessment of the phylogenetic characteristics, origins, history, and geographical evolution of SVA on a global scale, unlocking insights into developing efficient disease management strategies.
Keywords
