Lauric acid with or without levodopa ameliorates Parkinsonism in genetically modified model of Drosophila melanogaster via the oxidative–inflammatory–apoptotic pathway

Abstract

Abstract Background Parkinson's disease (PD), the most prevalent type of Parkinsonism, is a progressive neurological condition characterized by a range of motor and non‐motor symptoms. The complicated etiology of PD is thought to involve a summation of aging, genetic predisposition, and environmental variables. However, the α‐synuclein protein plays a significant role in the disease's pathophysiology. Materials and methods The UAS‐α‐Syn and Ddc‐Gal4 strains were crossed to produce offspring referred to as PD flies. The entire population of flies was divided into five groups, each having about 100 flies and five replicates. The control group (w1118) and the PD group not receiving treatment were exposed to lauric acid (LA)/levodopa (LD)‐free diet, while the PD groups that received treatments were fed with either a 250 mg/kg LA diet, a 250 mg/kg LD diet, or a combination of the two for 21 days. Longevity, geotaxis, and olfactory assays were performed in addition to other biochemical tests. Results As a result of the overexpression of α‐synuclein, the locomotive capacity, lifespan, and antioxidant status were all significantly (p < .05) reduced, and the apoptotic and neuroinflammatory activities were increased. Nevertheless, the majority of the treated flies improved significantly (p < .05). Conclusion LA, whether combined with LD or not, elicited a significant response in α‐synuclein/dopa decarboxylase genetically modified Drosophila melanogaster Parkinsonism models.

Keywords

• apoptosis
• dopa decarboxylase
• Drosophila melanogaster
• lauric acid
• neuroinflammation
• Parkinson's disease