Engineering (Jan 2023)
Physical Activity, Sedentary Behavior, and the Risk of Cardiovascular Disease in Type 2 Diabetes Mellitus Patients: The MIDiab Study
- Yafei Wu,
- Guijun Qin,
- Guixia Wang,
- Libin Liu,
- Bing Chen,
- Qingbo Guan,
- Zhongshang Yuan,
- Xu Hou,
- Ling Gao,
- Chao Xu,
- Haiqing Zhang,
- Xu Zhang,
- Qiu Li,
- Yongfeng Song,
- Fei Jing,
- Shizhan Ma,
- Shanshan Shao,
- Meng Zhao,
- Qingling Guo,
- Nanwei Tong,
- Hongyan Zhao,
- Xiaomin Xie,
- Chao Liu,
- Zhongyan Shan,
- Zhifeng Cheng,
- Xuefeng Yu,
- Shulin Chen,
- Tao Yang,
- Yangang Wang,
- Dongmei Li,
- Zhaoli Yan,
- Lixin Guo,
- Qiuhe Ji,
- Wenjuan Wang,
- Jiajun Zhao
Affiliations
- Yafei Wu
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Guijun Qin
- Department of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
- Guixia Wang
- Department of Endocrinology and Metabolism, First Hospital of Jilin University, Changchun 130021, China
- Libin Liu
- Department of Endocrinology and Metabolism, Fujian Medical University Union Hospital, Fuzhou 350001, China
- Bing Chen
- Endocrinology Department, The Southwest Hospital of AMU, Chongqing 400038, China
- Qingbo Guan
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Zhongshang Yuan
- Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China
- Xu Hou
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Ling Gao
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Chao Xu
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Haiqing Zhang
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Xu Zhang
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Qiu Li
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Yongfeng Song
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Fei Jing
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Shizhan Ma
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Shanshan Shao
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Meng Zhao
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Qingling Guo
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China
- Nanwei Tong
- Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu 610041, China
- Hongyan Zhao
- Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
- Xiaomin Xie
- Department of Endocrinology, The First People’s Hospital of Yinchuan, Yinchuan 750001, China
- Chao Liu
- Department of Endocrinology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital (the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine), Nanjing 210046, China
- Zhongyan Shan
- Department of Endocrinology and Metabolism & Institute of Endocrinology, the First Hospital of China Medical University, Shenyang 110000, China
- Zhifeng Cheng
- Department of Endocrinology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China
- Xuefeng Yu
- Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
- Shulin Chen
- Department of Endocrinology, Yantai Yuhuangding Hospital Affiliated to Qingdao University Medical College, Yantai 264000, China
- Tao Yang
- Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
- Yangang Wang
- Department of Endocrinology and Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao 266000, China
- Dongmei Li
- Division of Endocrinology, Department of Internal Medicine, Inner Mongolia Autonomous Region People’s Hospital, Hohhot 010017, China
- Zhaoli Yan
- Department of Endocrinology, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China
- Lixin Guo
- Department of Endocrinology & Beijing Institute of Geriatrics, National Health Commission, Beijing Hospital, Beijing 100000, China; Corresponding authors.
- Qiuhe Ji
- Division of Endocrinology, Department of Internal Medicine, Xijing Hospital of Air Force Military Medical University, Xi’an 710032, China; Corresponding authors.
- Wenjuan Wang
- National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100032, China; Corresponding authors.
- Jiajun Zhao
- Department of Endocrinology & Shandong Clinical Research Center of Diabetes and Metabolic Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China; Shandong Key Laboratory of Endocrinology and Lipid Metabolism & Shandong Prevention and Control Engineering Laboratory of Endocrine and Metabolic Diseases, Shandong First Medical University, Jinan 250021, China; Department of Endocrinology, Shandong Provincial Hospital, Shandong University, Jinan 250021, China; Corresponding authors.
- Journal volume & issue
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Vol. 20
pp. 26 – 35
Abstract
The aim of this study was to explore the associations of moderate-to-vigorous-intensity physical activity (MVPA) time and sedentary (SED) time with a history of cardiovascular disease (CVD) and multifactorial (i.e., blood pressure (BP), body mass index (BMI), low-density lipoprotein cholesterol (LDL-C), and glycated hemoglobin A1c (HbA1c)) control status among type 2 diabetes mellitus (T2DM) patients in China. A cross-sectional analysis of 9152 people with type 2 diabetes from the Multifactorial Intervention on Type 2 Diabetes (MIDiab) study was performed. Patients were grouped according to their self-reported MVPA time (low, < 150 min·week−1; moderate, 150 to < 450 min·week−1; high, ≥ 450 min·week−1) and SED time (low, < 4 h·d–1; moderate, 4 to < 8 h·d–1; high, ≥ 8 h·d–1). Participants who self-reported a history of CVD were identified as having a CVD risk. Odds ratios (ORs) and 95% confidence intervals (CIs) of CVD risk and multifactorial control status associated with MVPA time and SED time were estimated using mixed-effect logistic regression models, adjusting for China’s geographical region characteristics. The participants had a mean ± standard deviation (SD) age of (60.87 ± 8.44) years, 44.5% were women, and 25.1% had CVD. After adjustment for potential confounding factors, an inverse association between high MVPA time and CVD risk that was independent of SED time was found, whereas this association was not observed in the moderate-MVPA group. A higher MVPA time was more likely to have a positive effect on the control of BMI. Compared with the reference group (i.e., those with MVPA time ≥ 450 min·week−1 and SED time < 4 h·d–1), CVD risk was higher in the low-MVPA group: The OR associated with an SED time < 4 h·d–1 was 1.270 (95% CI, 1.040–1.553) and that associated with an SED time ≥ 8 h·d–1 was 1.499 (95% CI, 1.149–1.955). We found that a high MVPA time (i.e., ≥ 450 min·week−1) was associated with lower odds of CVD risk regardless of SED time among patients with T2DM.
