Communications Biology (Nov 2021)
Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator
- Mitsuhiro Yamada,
- Ikuko N. Motoike,
- Kaname Kojima,
- Nobuo Fuse,
- Atsushi Hozawa,
- Shinichi Kuriyama,
- Fumiki Katsuoka,
- Shu Tadaka,
- Matsuyuki Shirota,
- Miyuki Sakurai,
- Tomohiro Nakamura,
- Yohei Hamanaka,
- Kichiya Suzuki,
- Junichi Sugawara,
- Soichi Ogishima,
- Akira Uruno,
- Eiichi N. Kodama,
- Naoya Fujino,
- Tadahisa Numakura,
- Tomohiro Ichikawa,
- Ayumi Mitsune,
- Takashi Ohe,
- Kengo Kinoshita,
- Masakazu Ichinose,
- Hisatoshi Sugiura,
- Masayuki Yamamoto
Affiliations
- Mitsuhiro Yamada
- Department of Respiratory Medicine, Tohoku University Graduate School of Medicine
- Ikuko N. Motoike
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Kaname Kojima
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Nobuo Fuse
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Atsushi Hozawa
- Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University
- Shinichi Kuriyama
- Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University
- Fumiki Katsuoka
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Shu Tadaka
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Matsuyuki Shirota
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Miyuki Sakurai
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Tomohiro Nakamura
- Department of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University
- Yohei Hamanaka
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Kichiya Suzuki
- Department of Biobank, Tohoku Medical Megabank Organization, Tohoku University
- Junichi Sugawara
- Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University
- Soichi Ogishima
- Department of Health Record Informatics, Tohoku Medical Megabank Organization, Tohoku University
- Akira Uruno
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Eiichi N. Kodama
- Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University
- Naoya Fujino
- Department of Respiratory Medicine, Tohoku University Graduate School of Medicine
- Tadahisa Numakura
- Department of Respiratory Medicine, Tohoku University Graduate School of Medicine
- Tomohiro Ichikawa
- Department of Respiratory Medicine, Tohoku University Graduate School of Medicine
- Ayumi Mitsune
- Department of Respiratory Medicine, Tohoku University Graduate School of Medicine
- Takashi Ohe
- Department of Respiratory Medicine, Tohoku University Graduate School of Medicine
- Kengo Kinoshita
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- Masakazu Ichinose
- Osaki Citizen Hospital Academic Center
- Hisatoshi Sugiura
- Department of Respiratory Medicine, Tohoku University Graduate School of Medicine
- Masayuki Yamamoto
- Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University
- DOI
- https://doi.org/10.1038/s42003-021-02813-8
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 15
Abstract
Yamada, Motoike, Kojima et al. undertake a GWAS study on 19,722 participants from two Japanese populations for lung function with adjustment for fractional exhaled nitric oxide levels to account for airway inflammation. The authors identify variants of the RNF5/AGER locus and explore their three-dimensional protein interactions to better investigate the association between these variants and lung function.
