Nature Communications (Oct 2022)
HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids
- Manuela Völkner,
- Felix Wagner,
- Lisa Maria Steinheuer,
- Madalena Carido,
- Thomas Kurth,
- Ali Yazbeck,
- Jana Schor,
- Stephanie Wieneke,
- Lynn J. A. Ebner,
- Claudia Del Toro Runzer,
- David Taborsky,
- Katja Zoschke,
- Marlen Vogt,
- Sebastian Canzler,
- Andreas Hermann,
- Shahryar Khattak,
- Jörg Hackermüller,
- Mike O. Karl
Affiliations
- Manuela Völkner
- Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
- Felix Wagner
- Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
- Lisa Maria Steinheuer
- Department Computational Biology, Helmholtz Centre for Environmental Research—UFZ
- Madalena Carido
- Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
- Thomas Kurth
- Technische Universität Dresden, Center for Molecular and Cellular Bioengineering (CMCB), Technology Platform Core Facility Electron Microscopy and Histology
- Ali Yazbeck
- Department Computational Biology, Helmholtz Centre for Environmental Research—UFZ
- Jana Schor
- Department Computational Biology, Helmholtz Centre for Environmental Research—UFZ
- Stephanie Wieneke
- German Center for Neurodegenerative Diseases (DZNE) Dresden
- Lynn J. A. Ebner
- German Center for Neurodegenerative Diseases (DZNE) Dresden
- Claudia Del Toro Runzer
- German Center for Neurodegenerative Diseases (DZNE) Dresden
- David Taborsky
- German Center for Neurodegenerative Diseases (DZNE) Dresden
- Katja Zoschke
- German Center for Neurodegenerative Diseases (DZNE) Dresden
- Marlen Vogt
- Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
- Sebastian Canzler
- Department Computational Biology, Helmholtz Centre for Environmental Research—UFZ
- Andreas Hermann
- Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
- Shahryar Khattak
- Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
- Jörg Hackermüller
- Department Computational Biology, Helmholtz Centre for Environmental Research—UFZ
- Mike O. Karl
- Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden
- DOI
- https://doi.org/10.1038/s41467-022-33848-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 22
Abstract
Complex neuropathologies, like macular degeneration, are common but incompletely understood. Here the authors report a complex human retina pathology organoid model induced by HBEGF-TNF, causing PIEZO1-mediated photoreceptor degeneration by cell extrusion.
