Nature Communications (Aug 2016)
Dynamic clonal equilibrium and predetermined cancer risk in Barrett’s oesophagus
- Pierre Martinez,
- Margriet R. Timmer,
- Chiu T. Lau,
- Silvia Calpe,
- Maria del Carmen Sancho-Serra,
- Danielle Straub,
- Ann-Marie Baker,
- Sybren L. Meijer,
- Fiebo J. W. ten Kate,
- Rosalie C. Mallant-Hent,
- Anton H. J. Naber,
- Arnoud H. A. M. van Oijen,
- Lubbertus C. Baak,
- Pieter Scholten,
- Clarisse J. M. Böhmer,
- Paul Fockens,
- Jacques J. G. H. M. Bergman,
- Carlo C. Maley,
- Trevor A. Graham,
- Kausilia K Krishnadath
Affiliations
- Pierre Martinez
- Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London
- Margriet R. Timmer
- Department of Gastroenterology and Hepatology, Academic Medical Center—University of Amsterdam
- Chiu T. Lau
- Department of Gastroenterology and Hepatology, Academic Medical Center—University of Amsterdam
- Silvia Calpe
- Department of Gastroenterology and Hepatology, Academic Medical Center—University of Amsterdam
- Maria del Carmen Sancho-Serra
- Department of Gastroenterology and Hepatology, Academic Medical Center—University of Amsterdam
- Danielle Straub
- Department of Gastroenterology and Hepatology, Academic Medical Center—University of Amsterdam
- Ann-Marie Baker
- Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London
- Sybren L. Meijer
- Department of Pathology, Academic Medical Center—University of Amsterdam
- Fiebo J. W. ten Kate
- Department of Pathology, Academic Medical Center—University of Amsterdam
- Rosalie C. Mallant-Hent
- Department of Gastroenterology and Hepatology, Flevoziekenhuis
- Anton H. J. Naber
- Gastroenterological Association
- Arnoud H. A. M. van Oijen
- Gastroenterological Association
- Lubbertus C. Baak
- Gastroenterological Association
- Pieter Scholten
- Gastroenterological Association
- Clarisse J. M. Böhmer
- Gastroenterological Association
- Paul Fockens
- Department of Gastroenterology and Hepatology, Academic Medical Center—University of Amsterdam
- Jacques J. G. H. M. Bergman
- Department of Gastroenterology and Hepatology, Academic Medical Center—University of Amsterdam
- Carlo C. Maley
- Biodesign Institute, School of Life Sciences, Arizona State University
- Trevor A. Graham
- Evolution and Cancer Laboratory, Centre for Tumour Biology, Barts Cancer Institute, Queen Mary University of London
- Kausilia K Krishnadath
- Department of Gastroenterology and Hepatology, Academic Medical Center—University of Amsterdam
- DOI
- https://doi.org/10.1038/ncomms12158
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
Barrett’s oesophagus is thought to be a precursor lesion for oesophageal cancer, and predicting the benign lesions that progress to cancer is clinically important. Here, the authors use FISH to study the clonal evolution of Barrett’s oesophagus and show that genetic diversity and somatic mutations are present early in the benign disease.
