Антибиотики и Химиотерапия (Jun 2020)

Antiviral Activity of Kagocel<sup>®</sup> in vitro Against Virus SARS-CoV-2

  • S. Ya. Loginova,
  • V. N. Shchukina,
  • S. V. Savenko,
  • S. V. Borisevich

DOI
https://doi.org/10.37489/0235-2990-2020-65-3-4-3-6
Journal volume & issue
Vol. 65, no. 3-4
pp. 3 – 6

Abstract

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The antiviral activity of the drug Kagocel®, which has a high safety profile and proven efficacy for the prevention and treatment of influenza and AVRI as an interferon inducer, was studied against a new pandemic strain of SARS-CoV-2 in vitro in Vero C1008 cell culture. The results of the study revealed that at the addition of the substance Kagocel® at the concentration of 5000 pg/ml into the cell culture 1 h before the virus infection and 1 h after, there was 100% inhibition of the cytopathic activity of the virus. It was also found that Kagocel® at the dose of 5000 pg/ml effectively suppressed the reproduction of the SARS-CoV-2 virus, vari­ant B, in Vero C1008 cell culture by 1.75 lg, the inhibition coefficient was 97.83 %.

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