Communications Biology (Apr 2021)

A positive charge region of Salmonella FliI is required for ATPase formation and efficient flagellar protein export

  • Miki Kinoshita,
  • Keiichi Namba,
  • Tohru Minamino

DOI
https://doi.org/10.1038/s42003-021-01980-y
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 14

Abstract

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Kinoshita, Namba and Minamino show that a cluster of positively-charged arginines in the Salmonella FliI is necessary for formation of the FliI homo-hexamer ATPase. Through loss- and gain-of-function experiments, they demonstrate that hexamer assembly is also responsible for efficient export of flagellar proteins during flagellar assembly.