P96

Abstract

Obesity, associated with metabolic syndrome, is considered a significant risk factor for colorectal cancer (CRC). To compare the levels of metabolic syndrome (MS) components in persons with CRC and control in the frame of nested “case-control” design. Materials and Methods: The study was carried out on the basis of a comparison of databases from epidemiological study The HAPIEE project and CRC register. The patients examined in the HAPIEE project, who had developed CRC during 10-year follow-up period according to the register of cancer (n = 92, men-48, women-44, mean age 60.7 + 6.9 years) were included in analysis. The control group, matched by sex and age, was also formed from the HAPIEE database (n = 184, men-96, women-88, mean age 60.7 + 6.8 years). We used MS criteria’s according to NCEP ATP – III (2001). The data was processed using statistical program SPSS 13.0. Results: Body mass index (BMI) and waist circumference (WC) had no significant differences in the studied groups, the average BMI value in CRC group was 28.6 + 5.3 kg/m2 vs 28.4 + 5.6 kg/m2 in control (p = 0.70) and WC value in CRC group was 94.1 + 11.7 cm vs 94.1 + 13.6 cm in control (p = 0.90). The percentage of patients with abdominal obesity was 41.3% in patients with CRC vs 42.9% in the control group (p = 0.70). The average value of total cholesterol was equally high in both groups (246.8 + 52.5 mg/dL in patients with CRC and 239.8 + 47.0 mg/dL in the control group), with large individual variation but no significant difference (p = 0.27). The average level of HDL cholesterol in CRC group was within normal limits and also did not differ from control (p = 0.60). The average level of TG in CRC patients was slightly lower than in the control group: 127.2 + 58.5 mg/dl vs 144.6 + 80.8 mg/dL (p = 0.07). The average level of glucose did not differ in patients with CRC and in control: 5.9 + 1,2 mmol/l vs 6.1 + 2.1 mmol/L (p = 0.40). In patients with CRC systolic blood pressure was significantly lower than in control group: 142.1 + 21.3 mmHg vs 150.4 + 23.7 mmHg (p = 0.005). The level of diastolic blood pressure was slightly lower than in the control group compared to CRC (88.9 + 11.2 mmHg vs91.9 + 13.4 mmHg, p = 0.06). The proportions of patients with low HDL cholesterol, hypertriglyceridemia and hyperglycemia did not differ between the studied groups, but proportion of hypertension among controls was higher compared to the patients with CRC (85.3% vs 69.6% p = 0.002). Conclusions: In studied sample, we did not found the differences in the values of anthropometric indicators of metabolic syndrome, cholesterol, HDL cholesterol, triglycerides and glucose between patients with colorectal cancer and control. Systolic and diastolic blood pressure as well as hypertension frequency were significantly lower in CRC group than in the control group. Further analysis including stage and localization of CRC is required. The HAPIEE project is supported by Wellcome Trust (WT081081AIA).