Nature Communications (Nov 2022)
Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase
- Junli Zhao,
- Jinyi Sun,
- Yang Zheng,
- Yanrong Zheng,
- Yuying Shao,
- Yulan Li,
- Fan Fei,
- Cenglin Xu,
- Xiuxiu Liu,
- Shuang Wang,
- Yeping Ruan,
- Jinggen Liu,
- Shumin Duan,
- Zhong Chen,
- Yi Wang
Affiliations
- Junli Zhao
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Jinyi Sun
- Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University
- Yang Zheng
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Yanrong Zheng
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Yuying Shao
- Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University
- Yulan Li
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Fan Fei
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Cenglin Xu
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Xiuxiu Liu
- Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University
- Shuang Wang
- Epilepsy Center, Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University
- Yeping Ruan
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Jinggen Liu
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Shumin Duan
- Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Brain Science and Brain Medicine, Zhejiang University
- Zhong Chen
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- Yi Wang
- Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province, School of Pharmaceutical Sciences, Zhejiang Chinese Medical University
- DOI
- https://doi.org/10.1038/s41467-022-34662-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
Neocortical epilepsy is resistant to current treatments. Zhao et al. report that optogenetic stimulation of astrocytes effectively attenuates seizures via driving Na+-K+-ATPase, indicating a potential treatment strategy for intractable epilepsy.
