Nature Communications (Nov 2022)
Altered developmental programs and oriented cell divisions lead to bulky bones during salamander limb regeneration
- Marketa Kaucka,
- Alberto Joven Araus,
- Marketa Tesarova,
- Joshua D. Currie,
- Johan Boström,
- Michaela Kavkova,
- Julian Petersen,
- Zeyu Yao,
- Anass Bouchnita,
- Andreas Hellander,
- Tomas Zikmund,
- Ahmed Elewa,
- Phillip T. Newton,
- Ji-Feng Fei,
- Andrei S. Chagin,
- Kaj Fried,
- Elly M. Tanaka,
- Jozef Kaiser,
- András Simon,
- Igor Adameyko
Affiliations
- Marketa Kaucka
- Max Planck Institute for Evolutionary Biology
- Alberto Joven Araus
- Department of Cell and Molecular Biology, Biomedicum, Karolinska Institute
- Marketa Tesarova
- Central European Institute of Technology, Brno University of Technology
- Joshua D. Currie
- Department of Biology, Wake Forest University
- Johan Boström
- Department of Neuroimmunology, Center for Brain Research, Medical University Vienna
- Michaela Kavkova
- Central European Institute of Technology, Brno University of Technology
- Julian Petersen
- Department of Neuroimmunology, Center for Brain Research, Medical University Vienna
- Zeyu Yao
- Department of Cell and Molecular Biology, Biomedicum, Karolinska Institute
- Anass Bouchnita
- Department of Information Technology, Uppsala University
- Andreas Hellander
- Department of Information Technology, Uppsala University
- Tomas Zikmund
- Central European Institute of Technology, Brno University of Technology
- Ahmed Elewa
- Department of Cell and Molecular Biology, Biomedicum, Karolinska Institute
- Phillip T. Newton
- Department of Women’s and Children’s Health, Karolinska Institute
- Ji-Feng Fei
- The Research Institute of Molecular Pathology (IMP)
- Andrei S. Chagin
- Department of Physiology and Pharmacology, Karolinska Institutet
- Kaj Fried
- Department of Neuroscience, Biomedicum, Karolinska Institute
- Elly M. Tanaka
- The Research Institute of Molecular Pathology (IMP)
- Jozef Kaiser
- Central European Institute of Technology, Brno University of Technology
- András Simon
- Department of Cell and Molecular Biology, Biomedicum, Karolinska Institute
- Igor Adameyko
- Department of Neuroimmunology, Center for Brain Research, Medical University Vienna
- DOI
- https://doi.org/10.1038/s41467-022-34266-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
Normal limb development relies on synchronized formation of cartilage and bone. Here, the authors show that in salamander limb regeneration these processes are decoupled: ossification occurs after the final size of regenerating cartilage is reached, allowing fast regeneration and leading to bulky bones.
