Nature Communications (May 2020)
Translational control of breast cancer plasticity
- Michael Jewer,
- Laura Lee,
- Matthew Leibovitch,
- Guihua Zhang,
- Jiahui Liu,
- Scott D. Findlay,
- Krista M. Vincent,
- Kristofferson Tandoc,
- Dylan Dieters-Castator,
- Daniela F. Quail,
- Indrani Dutta,
- Mackenzie Coatham,
- Zhihua Xu,
- Aakshi Puri,
- Bo-Jhih Guan,
- Maria Hatzoglou,
- Andrea Brumwell,
- James Uniacke,
- Christos Patsis,
- Antonis Koromilas,
- Julia Schueler,
- Gabrielle M. Siegers,
- Ivan Topisirovic,
- Lynne-Marie Postovit
Affiliations
- Michael Jewer
- Department of Anatomy and Cell Biology, University of Western Ontario
- Laura Lee
- Department of Oncology, University of Alberta
- Matthew Leibovitch
- Lady Davis Institute, Departments of Oncology and Biochemistry, Division of Experimental Medicine, McGill University
- Guihua Zhang
- Department of Oncology, University of Alberta
- Jiahui Liu
- Department of Oncology, University of Alberta
- Scott D. Findlay
- Department of Anatomy and Cell Biology, University of Western Ontario
- Krista M. Vincent
- Department of Anatomy and Cell Biology, University of Western Ontario
- Kristofferson Tandoc
- Lady Davis Institute, Departments of Oncology and Biochemistry, Division of Experimental Medicine, McGill University
- Dylan Dieters-Castator
- Department of Anatomy and Cell Biology, University of Western Ontario
- Daniela F. Quail
- Goodman Cancer Center, McGill University
- Indrani Dutta
- Department of Oncology, University of Alberta
- Mackenzie Coatham
- Department of Oncology, University of Alberta
- Zhihua Xu
- Department of Oncology, University of Alberta
- Aakshi Puri
- Lady Davis Institute, Departments of Oncology and Biochemistry, Division of Experimental Medicine, McGill University
- Bo-Jhih Guan
- Department of Pharmacology, Case Western Reserve University
- Maria Hatzoglou
- Department of Pharmacology, Case Western Reserve University
- Andrea Brumwell
- Department of Molecular and Cellular Biology, University of Guelph
- James Uniacke
- Department of Molecular and Cellular Biology, University of Guelph
- Christos Patsis
- Lady Davis Institute, Departments of Oncology and Biochemistry, Division of Experimental Medicine, McGill University
- Antonis Koromilas
- Lady Davis Institute, Departments of Oncology and Biochemistry, Division of Experimental Medicine, McGill University
- Julia Schueler
- Charles River Discovery Research Services Germany
- Gabrielle M. Siegers
- Department of Oncology, University of Alberta
- Ivan Topisirovic
- Lady Davis Institute, Departments of Oncology and Biochemistry, Division of Experimental Medicine, McGill University
- Lynne-Marie Postovit
- Department of Oncology, University of Alberta
- DOI
- https://doi.org/10.1038/s41467-020-16352-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 16
Abstract
Protein synthesis suppression protects breast cancer cells from clinically relevant stresses like hypoxia. Here, the authors show that unique mRNA isoforms that govern stem cell-like phenotypes escape translational repression to drive tumor progression and chemoresistance.
