Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy

Zhenqi Jiang; Bo Yuan; Nianxiang Qiu; Yinjie Wang; Li Sun; Zhenni Wei; Yanyin Li; Jianjun Zheng; Yinhua Jin; Yong Li; Shiyu Du; Juan Li; Aiguo Wu

doi:10.1007/s40820-019-0292-y

Nano-Micro Letters (Jul 2019)

Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy

Zhenqi Jiang,
Bo Yuan,
Nianxiang Qiu,
Yinjie Wang,
Li Sun,
Zhenni Wei,
Yanyin Li,
Jianjun Zheng,
Yinhua Jin,
Yong Li,
Shiyu Du,
Juan Li,
Aiguo Wu

Affiliations

Zhenqi Jiang: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Bo Yuan: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Nianxiang Qiu: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Yinjie Wang: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Li Sun: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Zhenni Wei: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Yanyin Li: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Jianjun Zheng: Hwa Mei Hospital, University of Chinese Academy of Sciences
Yinhua Jin: Hwa Mei Hospital, University of Chinese Academy of Sciences
Yong Li: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Shiyu Du: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Juan Li: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences
Aiguo Wu: Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences

DOI: https://doi.org/10.1007/s40820-019-0292-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Abstract Zeolitic imidazolate frameworks (ZIFs) as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy. However, the exploration of ZIFs in biomedicine still encounters many issues, such as inconvenient surface modification, fast drug release during blood circulation, undesired damage to major organs, and severe in vivo toxicity. To address the above issues, we developed an Mn-ZIF-90 nanosystem functionalized with an originally designed active-targeting and pH-responsive magnetic resonance imaging (MRI) Y1 receptor ligand [Asn28, Pro30, Trp32]-NPY (25–36) for imaging-guided tumor therapy. After Y1 receptor ligand modification, the Mn-ZIF-90 nanosystem exhibited high drug loading, better blood circulation stability, and dual breast cancer cell membrane and mitochondria targetability, further favoring specific microenvironment-triggered tumor therapy. Meanwhile, this nanosystem showed promising T1-weighted magnetic resonance imaging contrast in vivo in the tumor sites. Especially, this nanosystem with fast clean-up had almost no obvious toxicity and no damage occurred to the major organs in mice. Therefore, this nanosystem shows potential for use in imaging-guided tumor therapy.

Published in Nano-Micro Letters

ISSN: 2311-6706 (Print); 2150-5551 (Online)
Publisher: SpringerOpen
Country of publisher: Germany
LCC subjects: Technology
Website: http://www.springer.com/40820

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