Nature Communications (May 2017)
Hepatic p63 regulates steatosis via IKKβ/ER stress
- Begoña Porteiro,
- Marcos F. Fondevila,
- Teresa C. Delgado,
- Cristina Iglesias,
- Monica Imbernon,
- Paula Iruzubieta,
- Javier Crespo,
- Amaia Zabala-Letona,
- Johan Fernø,
- Bárbara González-Terán,
- Nuria Matesanz,
- Lourdes Hernández-Cosido,
- Miguel Marcos,
- Sulay Tovar,
- Anxo Vidal,
- Julia Sánchez-Ceinos,
- Maria M. Malagon,
- Celia Pombo,
- Juan Zalvide,
- Arkaitz Carracedo,
- Xabier Buque,
- Carlos Dieguez,
- Guadalupe Sabio,
- Miguel López,
- Patricia Aspichueta,
- María L. Martínez-Chantar,
- Ruben Nogueiras
Affiliations
- Begoña Porteiro
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Marcos F. Fondevila
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Teresa C. Delgado
- CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)
- Cristina Iglesias
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Monica Imbernon
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Paula Iruzubieta
- CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)
- Javier Crespo
- CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)
- Amaia Zabala-Letona
- CIC bioGUNE, Centro de Investigación Biomédica en Red de Cáncer (CIBERonc)
- Johan Fernø
- Department of Clinical Science, KG Jebsen Center for Diabetes Research, University of Bergen
- Bárbara González-Terán
- Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
- Nuria Matesanz
- Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
- Lourdes Hernández-Cosido
- Department of General Surgery, Department of Surgery, Bariatric Surgery Unit, University Hospital of Salamanca, University of Salamanca
- Miguel Marcos
- Department of Internal Medicine, Department of Medicine, University Hospital of Salamanca-IBSAL, University of Salamanca
- Sulay Tovar
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Anxo Vidal
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Julia Sánchez-Ceinos
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)
- Maria M. Malagon
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn)
- Celia Pombo
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Juan Zalvide
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Arkaitz Carracedo
- CIC bioGUNE, Centro de Investigación Biomédica en Red de Cáncer (CIBERonc)
- Xabier Buque
- Department of Physiology, University of the Basque Country (UPV/EHU)
- Carlos Dieguez
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Guadalupe Sabio
- Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC)
- Miguel López
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- Patricia Aspichueta
- Department of Physiology, University of the Basque Country (UPV/EHU)
- María L. Martínez-Chantar
- CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)
- Ruben Nogueiras
- Department of Physiology, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria
- DOI
- https://doi.org/10.1038/ncomms15111
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 19
Abstract
p53 regulates lipid metabolism and fatty acid oxidation, and its inactivation promotes diet-induced liver steatosis. Here Porteiroet al. show that p53 deficiency leads to compensatory p63 upregulation, which, in turn, triggers endoplasmic reticulum stress through IKKβ activation, fatty acid synthesis and lipid accumulation.
