MANF regulates hypothalamic control of food intake and body weight

Su Yang; Huiming Yang; Renbao Chang; Peng Yin; Yang Yang; Weili Yang; Shanshan Huang; Marta A. Gaertig; Shihua Li; Xiao-Jiang Li

doi:10.1038/s41467-017-00750-x

Nature Communications (Sep 2017)

MANF regulates hypothalamic control of food intake and body weight

Su Yang,
Huiming Yang,
Renbao Chang,
Peng Yin,
Yang Yang,
Weili Yang,
Shanshan Huang,
Marta A. Gaertig,
Shihua Li,
Xiao-Jiang Li

Affiliations

Su Yang: Department of Human Genetics, Emory University School of Medicine
Huiming Yang: Department of Human Genetics, Emory University School of Medicine
Renbao Chang: Department of Human Genetics, Emory University School of Medicine
Peng Yin: Department of Human Genetics, Emory University School of Medicine
Yang Yang: Department of Human Genetics, Emory University School of Medicine
Weili Yang: GHM Institute of CNS Regeneration, Jinan University
Shanshan Huang: Department of Human Genetics, Emory University School of Medicine
Marta A. Gaertig: Department of Human Genetics, Emory University School of Medicine
Shihua Li: Department of Human Genetics, Emory University School of Medicine
Xiao-Jiang Li: Department of Human Genetics, Emory University School of Medicine

DOI: https://doi.org/10.1038/s41467-017-00750-x
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 16

Abstract

Read online

MANF is a neurotrophic factor that is secreted but also mediates the unfolded protein response acting intracellularly. Here, the authors show that MANF expression in the brain is influenced by nutritional cues, and hypothalamic MANF influences food intake and systemic energy homeostasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal