npj Breast Cancer (Feb 2021)

Immune microenvironment and intrinsic subtyping in hormone receptor-positive/HER2-negative breast cancer

  • Gaia Griguolo,
  • Maria Vittoria Dieci,
  • Laia Paré,
  • Federica Miglietta,
  • Daniele Giulio Generali,
  • Antonio Frassoldati,
  • Luigi Cavanna,
  • Giancarlo Bisagni,
  • Federico Piacentini,
  • Enrico Tagliafico,
  • Katia Cagossi,
  • Guido Ficarra,
  • Aleix Prat,
  • Pierfranco Conte,
  • Valentina Guarneri

DOI
https://doi.org/10.1038/s41523-021-00223-x
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 5

Abstract

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Abstract Little is known regarding the interaction between immune microenvironment and tumor biology in hormone receptor (HR)+/HER2− breast cancer (BC). We here assess pretreatment gene-expression data from 66 HR+/HER2− early BCs from the LETLOB trial and show that non-luminal tumors (HER2-enriched, Basal-like) present higher tumor-infiltrating lymphocyte levels than luminal tumors. Moreover, significant differences in immune infiltrate composition, assessed by CIBERSORT, were observed: non-luminal tumors showed a more proinflammatory antitumor immune infiltrate composition than luminal ones.