Study on the interaction between different pathogens of Hand, foot and mouth disease in five regions of China

Zimei Yang; Jia Rui; Li Qi; Wenjing Ye; Yan Niu; Kaiwei Luo; Bin Deng; Shi Zhang; Shanshan Yu; Chan Liu; Peihua Li; Rui Wang; Hongjie Wei; Hesong Zhang; Lijin Huang; Simiao Zuo; Lexin Zhang; Shurui Zhang; Shiting Yang; Yichao Guo; Qinglong Zhao; Shenggen Wu; Qin Li; Yong Chen; Tianmu Chen

doi:10.3389/fpubh.2022.970880

Frontiers in Public Health (Sep 2022)

Study on the interaction between different pathogens of Hand, foot and mouth disease in five regions of China

Zimei Yang,
Jia Rui,
Li Qi,
Wenjing Ye,
Yan Niu,
Kaiwei Luo,
Bin Deng,
Shi Zhang,
Shanshan Yu,
Chan Liu,
Peihua Li,
Rui Wang,
Hongjie Wei,
Hesong Zhang,
Lijin Huang,
Simiao Zuo,
Lexin Zhang,
Shurui Zhang,
Shiting Yang,
Yichao Guo,
Qinglong Zhao,
Shenggen Wu,
Qin Li,
Yong Chen,
Tianmu Chen

Affiliations

Zimei Yang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Jia Rui: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Li Qi: Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China
Wenjing Ye: Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, China
Yan Niu: Chinese Center for Disease Control and Prevention, Beijing, China
Kaiwei Luo: Hunan Center for Disease Control and Prevention, Changsha, Hunan, China
Bin Deng: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Shi Zhang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Shanshan Yu: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Chan Liu: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Peihua Li: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Rui Wang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Hongjie Wei: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Hesong Zhang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Lijin Huang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Simiao Zuo: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Lexin Zhang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Shurui Zhang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Shiting Yang: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Yichao Guo: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China
Qinglong Zhao: Jilin Center for Disease Control and Prevention, Changchun, Jilin, China
Shenggen Wu: Fujian Center for Disease Control and Prevention, Fuzhou, Fujian, China
Qin Li: Chongqing Municipal Center for Disease Control and Prevention, Chongqing, China
Yong Chen: Department of Stomatology, School of Medicine, Xiamen University, Xiamen, China
Tianmu Chen: State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian, China

DOI: https://doi.org/10.3389/fpubh.2022.970880
Journal volume & issue: Vol. 10

Abstract

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ObjectivesThis study aims to explore the interaction of different pathogens in Hand, foot and mouth disease (HFMD) by using a mathematical epidemiological model and the reported data in five regions of China.MethodsA cross-regional dataset of reported HFMD cases was built from four provinces (Fujian Province, Jiangsu province, Hunan Province, and Jilin Province) and one municipality (Chongqing Municipality) in China. The subtypes of the pathogens of HFMD, including Coxsackievirus A16 (CV-A16), enteroviruses A71 (EV-A71), and other enteroviruses (Others), were included in the data. A mathematical model was developed to fit the data. The effective reproduction number (Reff) was calculated to quantify the transmissibility of the pathogens.ResultsIn total, 3,336,482 HFMD cases were collected in the five regions. In Fujian Province, the Reff between CV-A16 and EV-A71&CV-A16, and between CV-A16 and CV-A16&Others showed statistically significant differences (P < 0.05). In Jiangsu Province, there was a significant difference in Reff (P < 0.05) between the CV-A16 and Total. In Hunan Province, the Reff between CV-A16 and EV-A71&CV-A16, between CV-A16 and Total were significant (P < 0.05). In Chongqing Municipality, we found significant differences of the Reff (P < 0.05) between CV-A16 and CV-A16&Others, and between Others and CV-A16&Others. In Jilin Province, significant differences of the Reff (P < 0.05) were found between EV-A71 and Total, and between Others and Total.ConclusionThe major pathogens of HFMD have changed annually, and the incidence of HFMD caused by others and CV-A16 has surpassed that of EV-A71 in recent years. Cross-regional differences were observed in the interactions between the pathogens.

Published in Frontiers in Public Health

ISSN: 2296-2565 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Public aspects of medicine
Website: https://www.frontiersin.org/journals/public-health

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