Respiratory flora: The potential biomarker of radiation-induced pulmonary injury

Hongjuan Guo; Lili Wang; Wei Zhu; Xiaofei Qi; Qi Zhang; Yang Jiao; Jianping Cao

Radiation Medicine and Protection (Mar 2022)

Respiratory flora: The potential biomarker of radiation-induced pulmonary injury

Hongjuan Guo,
Lili Wang,
Wei Zhu,
Xiaofei Qi,
Qi Zhang,
Yang Jiao,
Jianping Cao

Affiliations

Hongjuan Guo: State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China; Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China
Lili Wang: Department of Radiotherapy, First Affiliated Hospital of Soochow University, Suzhou 215006, China
Wei Zhu: State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China; Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China
Xiaofei Qi: Department of Hematology, First Affiliated Hospital of Soochow University, Suzhou 215006, China
Qi Zhang: State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China; Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China
Yang Jiao: State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China; Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China; Corresponding author. State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.
Jianping Cao: State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China; Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China; Corresponding author. State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.

Journal volume & issue: Vol. 3, no. 1
pp. 43 – 46

Abstract

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Radiation-induced pulmonary injury is a major dose-limiting toxicity that occurs due to thoracic radiotherapy. And the most widely used high-throughput technology, 16S ribosomal RNA sequencing, is adopted for bacterial classification and identification of airway microbiome analysis. In this study, we provide novel insights into the composition pattern and predicted function of the lung microbiome in RIPI rats. Certain genus and species change in a dose-dependent manner, which might be capable of serving as novel bacterial biomarkers, as well as the potential targets for the future diagnosis or treatment of RIPI. In summary, our findings provide a vital reference for RIPI study, and will contribute to investigate the novel therapeutic or preventive management for RIPI.

Published in Radiation Medicine and Protection

ISSN: 2666-5557 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiation-medicine-and-protection

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Abstract

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