Nature Communications (Feb 2018)

A neuronal mechanism underlying decision-making deficits during hyperdopaminergic states

  • Jeroen P. H. Verharen,
  • Johannes W. de Jong,
  • Theresia J. M. Roelofs,
  • Christiaan F. M. Huffels,
  • Ruud van Zessen,
  • Mieneke C. M. Luijendijk,
  • Ralph Hamelink,
  • Ingo Willuhn,
  • Hanneke E. M. den Ouden,
  • Geoffrey van der Plasse,
  • Roger A. H. Adan,
  • Louk J. M. J. Vanderschuren

DOI
https://doi.org/10.1038/s41467-018-03087-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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Aberrant increased dopaminergic function results in impaired value-based decision making. Here the authors report pathway-specific effects of VTA activation on distinct aspects of flexible value-based decisions in rats.