Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

Minqing Jiang; Lei Liu; Xuelian He; Haibo Wang; Wensheng Lin; Huimin Wang; Sung O. Yoon; Teresa L. Wood; Q. Richard Lu

doi:10.1038/ncomms12185

Nature Communications (Jul 2016)

Regulation of PERK–eIF2α signalling by tuberous sclerosis complex-1 controls homoeostasis and survival of myelinating oligodendrocytes

Minqing Jiang,
Lei Liu,
Xuelian He,
Haibo Wang,
Wensheng Lin,
Huimin Wang,
Sung O. Yoon,
Teresa L. Wood,
Q. Richard Lu

Affiliations

Minqing Jiang: Key Laboratory of Brain Functional Genomics of STCSM, Institute of Cognitive Neuroscience, East China Normal University
Lei Liu: Department of Pediatrics, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Second Hospital, Sichuan University
Xuelian He: Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati
Haibo Wang: Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati
Wensheng Lin: Department of Neuroscience, Institute for Translational Neuroscience, University of Minnesota
Huimin Wang: Key Laboratory of Brain Functional Genomics of STCSM, Institute of Cognitive Neuroscience, East China Normal University
Sung O. Yoon: Department of Molecular and Cellular Biochemistry, Center for Molecular Neurobiology, The Ohio State University
Teresa L. Wood: Department of Neurology and Neuroscience, New Jersey Medical School Cancer Center, Rutgers Biomedical and Health Sciences
Q. Richard Lu: Department of Pediatrics, Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati

DOI: https://doi.org/10.1038/ncomms12185
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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The molecular mechanisms regulating myelination are only partially understood. Here authors show that Tsc1ablation in oligodendrocyte lineage activates ER stress and apoptotic programs in mice, and that enhancing PERK-eIF2α signalling partially rescues the myelination defects in Tsc1 mutants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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