Nature Communications (Oct 2019)

Bacterial variability in the mammalian gut captured by a single-cell synthetic oscillator

  • David T. Riglar,
  • David L. Richmond,
  • Laurent Potvin-Trottier,
  • Andrew A. Verdegaal,
  • Alexander D. Naydich,
  • Somenath Bakshi,
  • Emanuele Leoncini,
  • Lorena G. Lyon,
  • Johan Paulsson,
  • Pamela A. Silver

DOI
https://doi.org/10.1038/s41467-019-12638-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Synthetic gene oscillators can be used to control timed function and periodic expression of genes. Here the authors demonstrate in vivo implementation in the mammalian gut that can keep time over several days.