Catalytic Addition of Indole-2-Carboxylic Acid to 1-Hexyne

Abstract

The synthesis of two novel enol esters, namely hex-1-en-2-yl indole-2-carboxylate and hex-1-en-2-yl 1-(hex-1-en-2-yl)-indole-2-carboxylate, is presented. Both compounds were generated by addition of indole-2-carboxylic acid to 1-hexyne employing [RuCl2(η6-p-cymene)(PPh3)] and [AuCl(PPh3)]/AgPF6, respectively, as catalysts.

Keywords

• enol esters
• hydro-oxycarbonylation reactions
• hydroamination reactions
• ruthenium catalysts
• gold catalysts