Frontiers in Natural Products (Jan 2024)

Isolation of new neolignans and an unusual meroterpenoid from Piper cabagranum

  • Celso R. de Oliveira,
  • Zachary D. Ledvina,
  • Michael D. Leonard,
  • Samuel O. Odoh,
  • Craig D. Dodson,
  • Christopher S. Jeffrey

DOI
https://doi.org/10.3389/fntpr.2023.1332436
Journal volume & issue
Vol. 2

Abstract

Read online

A novel meroterpenoid cabagranin D was isolated with related neolignans cabagranins A–C from the leaves of Piper cabagranum (Costa Rica). Cabagranins A–C represent the first examples of 3,3′-neolignans isolated from the plant genus Piper, and the meroterpenoid cabagranin D displays an unprecedented Diels–Alder conjugate of an unsubstituted phenylpropenone and α-phellandrene. Details of the full structural elucidation of these compounds and a discussion of their potential biosynthetic relationships are presented.

Keywords