Nature Communications (Mar 2021)
Staphylococcus aureus induces an itaconate-dominated immunometabolic response that drives biofilm formation
- Kira L. Tomlinson,
- Tania Wong Fok Lung,
- Felix Dach,
- Medini K. Annavajhala,
- Stanislaw J. Gabryszewski,
- Ryan A. Groves,
- Marija Drikic,
- Nancy J. Francoeur,
- Shwetha H. Sridhar,
- Melissa L. Smith,
- Sara Khanal,
- Clemente J. Britto,
- Robert Sebra,
- Ian Lewis,
- Anne-Catrin Uhlemann,
- Barbara C. Kahl,
- Alice S. Prince,
- Sebastián A. Riquelme
Affiliations
- Kira L. Tomlinson
- Department of Pediatrics, Columbia University
- Tania Wong Fok Lung
- Department of Pediatrics, Columbia University
- Felix Dach
- Department of Pediatrics, Columbia University
- Medini K. Annavajhala
- Department of Medicine, Columbia University
- Stanislaw J. Gabryszewski
- Department of Pediatrics, Columbia University
- Ryan A. Groves
- Department of Biological Sciences, University of Calgary
- Marija Drikic
- Department of Biological Sciences, University of Calgary
- Nancy J. Francoeur
- Department of Genetics and Genomic Sciences, Mt. Sinai Icahn School of Medicine
- Shwetha H. Sridhar
- Department of Genetics and Genomic Sciences, Mt. Sinai Icahn School of Medicine
- Melissa L. Smith
- Department of Genetics and Genomic Sciences, Mt. Sinai Icahn School of Medicine
- Sara Khanal
- Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine
- Clemente J. Britto
- Section of Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine
- Robert Sebra
- Department of Genetics and Genomic Sciences, Mt. Sinai Icahn School of Medicine
- Ian Lewis
- Department of Biological Sciences, University of Calgary
- Anne-Catrin Uhlemann
- Department of Medicine, Columbia University
- Barbara C. Kahl
- Institute of Medical Microbiology Münster, University Hospital
- Alice S. Prince
- Department of Pediatrics, Columbia University
- Sebastián A. Riquelme
- Department of Pediatrics, Columbia University
- DOI
- https://doi.org/10.1038/s41467-021-21718-y
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
The authors show that the pathogen Staphylococcus aureus induces a distinct airway immunometabolic response, dominated by release of itaconate. This metabolite, in turn, potentiates extracellular polysaccharide synthesis and biofilm formation in S. aureus, which may facilitate chronic infection.
