Nature Communications (Oct 2017)

Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

  • Masahide Kawatou,
  • Hidetoshi Masumoto,
  • Hiroyuki Fukushima,
  • Gaku Morinaga,
  • Ryuzo Sakata,
  • Takashi Ashihara,
  • Jun K. Yamashita

DOI
https://doi.org/10.1038/s41467-017-01125-y
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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Torsade de Pointes (TdP) is a life-threatening ventricular arrhythmia often caused by drugs. In response to an urgent need for human tissue TdP models, here the authors describe a 3D human iPS cell-engineered heart tissue that generates TdP in response to drugs, providing a suitable model for studies of TdP mechanism and drug toxicity.