The Prevalence and Distribution of High Risk Human Papilloma Virus İnfection From Turkish Women with Normal Cytology: A Single Center Study

Abstract

Purpose: The aim of this study was to investigate the prevalence and age distribution of high risk human papilloma virus (hrHPV) infection from Turkish women with normal cytology. Materials and Methods: Our study population consisted of 4212 women with normal cytology and adequate hrHPV molecular testing. The cases were divided into 5 groups according to their age ranges as 21-25 years old, 25-29 years old, 30-44 years old, 45-54, and 55-65 years old. Groups were compared with hrHPV positivity and type 16/18 positivity. Results: Hr HPV was detected in 494 (11.73 %) of 4212 cases. The positivity of hr HPV were 31.97% in group 1 (21-24 years), 18.34% in group 2 (25-29 years), 11.29% in group 3 (30-44 years), 8.73% in group 4 (45-54 years), and 10.18% in group 5 (55-65 years) . There was statistically significant difference in the rates of hrHPV between group 1 and the other groups (p <0.05). There was statistically significant difference in the rates of hrHPV of group 2 and the other groups (p <0.05) . There was statistically significant difference in the rates of type 16 between groups 1 and the other groups (p <0.05). Conclusion: According to meta-analysis studies, hrHPV positivity has been reported in approximately 6.6% of women with normal cytology. This rate varies between 1.4% and 25.6%, being more frequent in societies with low-middle socioeconomic status. In this study, this rate was found to be 11.73% independent of age groups and was found to be consistent with the literature.

Keywords

• hrhpv
• type 16/18
• cervix
• normal cytology