Evaluation of Acute Oral Toxicity of Supramolecular Complex Based on Albendazole and Triclabendazole – Altrick-Extra in Laboratory Outbred Mice and Rats

Abstract

The purpose of the research is to assess the acute oral toxicity of the drug Altrik-Extra in mice and rats, to determine its hazard class depending on the degree of exposure to animals.Materials and methods. White outbred mice and rats were used in the experiment. In the study of acute oral toxicity, conventional techniques were used.Results and discussion. Average lethal doses of LD50 were established when administered orally to laboratory animals. For mice, LD50 was more than 5986 mg/kg. Thus, according to the generally accepted hygienic classification (GOST 12.1.007-76), Altrick- Extra belongs to the 4th hazard class (low-hazard substances). In the study of acute oral toxicity in rats, LD50 was 3 103.1±748.5 mg/kg (confidence interval boundaries 2 354.6÷3 851.5 mg/kg). Therefore, in accordance with GOST 12.1.007-76, the studied drug belongs to the 3rd class of danger (moderately dangerous substances).

Keywords

• altrick-extra
• albendazole
• triclabendazole
• acute toxicity
• mice
• rats