Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence

Zi-Lei Xia; Chao Zheng; Ren-Qi Xu; Shu-Li You

doi:10.1038/s41467-019-11109-9

Nature Communications (Jul 2019)

Chiral phosphoric acid catalyzed aminative dearomatization of α-naphthols/Michael addition sequence

Zi-Lei Xia,
Chao Zheng,
Ren-Qi Xu,
Shu-Li You

Affiliations

Zi-Lei Xia: State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Chao Zheng: State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Ren-Qi Xu: State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences
Shu-Li You: State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-11109-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 7

Abstract

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Catalytic asymmetric dearomatization (CADA) reactions readily convert common aromatic compounds to diverse 3D chiral, polycyclic molecules. Here, the authors report an intermolecular asymmetric dearomatization of nucleophile-tethered α-naphthols affording functionalized cyclic ketones with high enantioselectivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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