Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients

Juanjie Tang; Supriya Ravichandran; Youri Lee; Gabrielle Grubbs; Elizabeth M. Coyle; Laura Klenow; Hollie Genser; Hana Golding; Surender Khurana

doi:10.1038/s41467-021-21463-2

Nature Communications (Feb 2021)

Antibody affinity maturation and plasma IgA associate with clinical outcome in hospitalized COVID-19 patients

Juanjie Tang,
Supriya Ravichandran,
Youri Lee,
Gabrielle Grubbs,
Elizabeth M. Coyle,
Laura Klenow,
Hollie Genser,
Hana Golding,
Surender Khurana

Affiliations

Juanjie Tang: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
Supriya Ravichandran: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
Youri Lee: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
Gabrielle Grubbs: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
Elizabeth M. Coyle: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
Laura Klenow: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
Hollie Genser: Quest Diagnostics at Adventist Healthcare
Hana Golding: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA
Surender Khurana: Division of Viral Products, Center for Biologics Evaluation and Research (CBER), FDA

DOI: https://doi.org/10.1038/s41467-021-21463-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 13

Abstract

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SARS-CoV2 infection has been linked to a wide range of clinical severities and the immunopathology is still under intense scrutiny. Here, the authors uncover an association of antibody affinity maturation and plasma IgA levels with clinical outcome in patients with COVID-19 disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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