Molecules (Jul 2019)
Nervisides I–J: Unconventional Side-Chain-Bearing Cycloartane Glycosides from <i>Nervilia concolor</i>
Abstract
Two new cycloartane glycosides, nervisides I−J, were isolated from Nervilia concolor whole plants. Their structures were unambiguously established by interpretation of their HRESIMS and 1D and 2D NMR data. These cycloartanes comprised a stereogenic center at C-24, the R configuration of which was assigned based on DFT-NMR calculations and the subsequent DP4 probability score. These compounds were tested for cytotoxicity against K562 and MCF-7 tumor cell lines, revealing mild cytotoxic activity.
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