The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer

Soudeh Ghafouri-Fard; Sajad Najafi; Bashdar Mahmud Hussen; Abbas Basiri; Hazha Jamal Hidayat; Mohammad Taheri; Fariborz Rashnoo

doi:10.3389/fonc.2022.801842

Frontiers in Oncology (Feb 2022)

The Role of Circular RNAs in the Carcinogenesis of Bladder Cancer

Soudeh Ghafouri-Fard,
Sajad Najafi,
Bashdar Mahmud Hussen,
Abbas Basiri,
Hazha Jamal Hidayat,
Mohammad Taheri,
Fariborz Rashnoo

Affiliations

Soudeh Ghafouri-Fard: Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sajad Najafi: Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Bashdar Mahmud Hussen: Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil, Iraq
Abbas Basiri: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hazha Jamal Hidayat: Department of Biology, College of Education, Salahaddin University-Erbil, Erbil, Iraq
Mohammad Taheri: Institute of Human Genetics, Jena University Hospital, Jena, Germany
Fariborz Rashnoo: Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

DOI: https://doi.org/10.3389/fonc.2022.801842
Journal volume & issue: Vol. 12

Abstract

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Circular RNAs (circRNAs) are a group of transcripts with enclosed configurations which can regulate gene expression. These transcripts have important roles in normal development and in the pathogenesis of disorders. Recent evidence has supported involvement of circRNAs in the development of bladder cancer. Several circRNAs such as circ_0058063, hsa-circRNA-403658, circPDSS1, circCASC15, circRNA-MYLK, and circRNA_103809 have been upregulated in bladder cancer samples. On the other hand, hsa_circ_0137606, BCRC-3, circFUT8, hsa_circ_001598, circSLC8A1, hsa_circ_0077837, hsa_circ_0004826, and circACVR2A are among downregulated circRNAs in bladder cancer. Numerous circRNAs have diagnostic or prognostic value in bladder cancer. In this review, we aim to outline the latest findings about the role of circRNAs in bladder cancer and introduce circRNAs for further investigations as therapeutic targets.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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