The Application of Clinical Genetics (Aug 2016)
The association between vitamin D receptor gene polymorphisms (TaqI and FokI), Type 2 diabetes, and micro-/macrovascular complications in postmenopausal women
Abstract
Juliana Maia,1 Andreia Soares da Silva,2 Rodrigo Feliciano do Carmo,3 Taciana Furtado de Mendonça,2 Luiz Henrique Maciel Griz,1 Patricia Moura,2 Francisco Bandeira1 1Division of Endocrinology and Diabetes, Agamenon Magalhães Hospital, 2Institute of Biological Sciences, University of Pernambuco Medical School, Recife, 3Federal University of São Francisco Valley, Petrolina, Pernambuco, Brazil Introduction: Since there is evidence of the action of vitamin D as a modulator of insulin release and atherosclerosis, it may well be that the vitamin D receptor polymorphisms are associated with diabetes and its chronic complications. Aims: To examine the associations between vitamin D receptor polymorphisms (FokI and TaqI) and Type 2 diabetes (T2DM) and its associated chronic complications in postmenopausal women. Methods: This cross-sectional study analyzed 100 postmenopausal women with T2DM (mean age 65.7±7.18 years) and 100 postmenopausal women without diabetes in the control group (mean age 65.1±9.18 years; P=0.1608). We evaluated clinical and metabolic parameters and analyzed TaqI and FokI polymorphisms. Results: There were no significant differences in genotype and allele frequencies between patients and controls in either of the polymorphisms studied. In the group of patients with diabetes, there were no significant differences in either polymorphism in relation to stroke, retinopathy, nephropathy, or neuropathy. However, in patients with T2DM and coronary artery disease, f genotype (P=0.0361) and the combination of Ff + ff genotypes were observed less frequently (P=0.0462).Conclusion: This study suggests the potential protective factor of FokI polymorphism for coronary artery disease in postmenopausal women with T2DM in the recessive model. Keywords: Type 2 diabetes, VDR, polymorphism, vitamin D
