Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?

Aaron Ermel; Aaron Ermel; Thankam Paul Thyvalikakath; Thankam Paul Thyvalikakath; Thankam Paul Thyvalikakath; Tatiana Foroud; Tatiana Foroud; Babar Khan; Babar Khan; Babar Khan; Mythily Srinivasan

doi:10.3389/fmicb.2021.727430

Frontiers in Microbiology (Oct 2021)

Can Salivary Innate Immune Molecules Provide Clue on Taste Dysfunction in COVID-19?

Aaron Ermel,
Aaron Ermel,
Thankam Paul Thyvalikakath,
Thankam Paul Thyvalikakath,
Thankam Paul Thyvalikakath,
Tatiana Foroud,
Tatiana Foroud,
Babar Khan,
Babar Khan,
Babar Khan,
Mythily Srinivasan

Affiliations

Aaron Ermel: Division of Infectious Diseases, Department of Internal Medicine, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States
Aaron Ermel: Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States
Thankam Paul Thyvalikakath: Department of Cariology, Operative Dentistry and Dental Public Health, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States
Thankam Paul Thyvalikakath: Indiana University School of Dentistry, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States
Thankam Paul Thyvalikakath: Regenstrief Institute, Inc., Indianapolis, IN, United States
Tatiana Foroud: Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States
Tatiana Foroud: Department of Medical and Molecular Genetics, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States
Babar Khan: Indiana University School of Medicine, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States
Babar Khan: Regenstrief Institute, Inc., Indianapolis, IN, United States
Babar Khan: Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States
Mythily Srinivasan: Department of Oral Pathology, Medicine and Radiology, Indiana University Purdue University at Indianapolis, Indianapolis, IN, United States

DOI: https://doi.org/10.3389/fmicb.2021.727430
Journal volume & issue: Vol. 12

Abstract

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Emerging concerns following the severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) pandemic are the long-term effects of coronavirus disease (COVID)-19. Dysgeusia in COVID-19 is supported by the abundant expression of the entry receptor, angiotensin-converting enzyme-2 (ACE2), in the oral mucosa. The invading virus perturbs the commensal biofilm and regulates the host responses that permit or suppress viral infection. We correlated the microbial recognition receptors and soluble ACE2 (sACE2) with the SARS-CoV2 measures in the saliva of COVID-19 patients. Data indicate that the toll-like receptor-4, peptidoglycan recognition protein, and sACE2 are elevated in COVID-19 saliva and correlate moderately with the viral load.

Published in Frontiers in Microbiology

ISSN: 1664-302X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.frontiersin.org/journals/microbiology

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Abstract

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