Nature Communications (Oct 2020)
c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis
- Yu Chen Feng,
- Xiao Ying Liu,
- Liu Teng,
- Qiang Ji,
- Yongyan Wu,
- Jin Ming Li,
- Wei Gao,
- Yuan Yuan Zhang,
- Ting La,
- Hessam Tabatabaee,
- Xu Guang Yan,
- M. Fairuz B. Jamaluddin,
- Didi Zhang,
- Su Tang Guo,
- Rodney J. Scott,
- Tao Liu,
- Rick F. Thorne,
- Xu Dong Zhang,
- Lei Jin
Affiliations
- Yu Chen Feng
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Xiao Ying Liu
- Translational Research Institute, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou
- Liu Teng
- Translational Research Institute, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou
- Qiang Ji
- Translational Research Institute, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou
- Yongyan Wu
- Department of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical University
- Jin Ming Li
- Translational Research Institute, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou
- Wei Gao
- Department of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical University
- Yuan Yuan Zhang
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Ting La
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Hessam Tabatabaee
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Xu Guang Yan
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- M. Fairuz B. Jamaluddin
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Didi Zhang
- Department of Orthopaedics, John Hunter Hospital, Hunter New England Health
- Su Tang Guo
- Department of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan
- Rodney J. Scott
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Tao Liu
- Children’s Cancer Institute Australia for Medical Research, University of New South Wales
- Rick F. Thorne
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Xu Dong Zhang
- School of Biomedical Sciences and Pharmacy, The University of Newcastle
- Lei Jin
- Translational Research Institute, Henan Provincial People’s Hospital and People’s Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou
- DOI
- https://doi.org/10.1038/s41467-020-18735-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
c-Myc and p53 operate in a negative feedback manner to maintain cellular homeostasis. Here, the authors report a long noncoding RNA, MILIP as a downstream target of c-Myc and that MILIP represses p53 to support tumorigenicity.
