Brain-to-cervical lymph node signaling after stroke

Elga Esposito; Bum Ju Ahn; Jingfei Shi; Yoshihiko Nakamura; Ji Hyun Park; Emiri T. Mandeville; Zhanyang Yu; Su Jing Chan; Rakhi Desai; Ayumi Hayakawa; Xunming Ji; Eng H. Lo; Kazuhide Hayakawa

doi:10.1038/s41467-019-13324-w

Nature Communications (Nov 2019)

Brain-to-cervical lymph node signaling after stroke

Elga Esposito,
Bum Ju Ahn,
Jingfei Shi,
Yoshihiko Nakamura,
Ji Hyun Park,
Emiri T. Mandeville,
Zhanyang Yu,
Su Jing Chan,
Rakhi Desai,
Ayumi Hayakawa,
Xunming Ji,
Eng H. Lo,
Kazuhide Hayakawa

Affiliations

Elga Esposito: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Bum Ju Ahn: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Jingfei Shi: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Yoshihiko Nakamura: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Ji Hyun Park: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Emiri T. Mandeville: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Zhanyang Yu: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Su Jing Chan: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Rakhi Desai: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Ayumi Hayakawa: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Xunming Ji: China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University
Eng H. Lo: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School
Kazuhide Hayakawa: Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-019-13324-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate inflammatory responses in the draining cervical lymph nodes to induce systemic inflammation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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