The Breadth and Molecular Basis of Hcp-Driven Type VI Secretion System Effector Delivery

Sophie A. Howard; R. Christopher D. Furniss; Dora Bonini; Himani Amin; Patricia Paracuellos; David Zlotkin; Tiago R. D. Costa; Asaf Levy; Despoina A. I. Mavridou; Alain Filloux

doi:10.1128/mBio.00262-21

mBio (Jun 2021)

The Breadth and Molecular Basis of Hcp-Driven Type VI Secretion System Effector Delivery

Sophie A. Howard,
R. Christopher D. Furniss,
Dora Bonini,
Himani Amin,
Patricia Paracuellos,
David Zlotkin,
Tiago R. D. Costa,
Asaf Levy,
Despoina A. I. Mavridou,
Alain Filloux

Affiliations

Sophie A. Howard: Imperial College London, Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, London, United Kingdom
R. Christopher D. Furniss: ORCiD; Science for Life Laboratory, Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
Dora Bonini: Imperial College London, Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, London, United Kingdom
Himani Amin: Imperial College London, Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, London, United Kingdom
Patricia Paracuellos: Imperial College London, Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, London, United Kingdom
David Zlotkin: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Tiago R. D. Costa: Imperial College London, Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, London, United Kingdom
Asaf Levy: Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
Despoina A. I. Mavridou: ORCiD; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA
Alain Filloux: ORCiD; Imperial College London, Department of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, London, United Kingdom

DOI: https://doi.org/10.1128/mBio.00262-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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The type VI secretion system (T6SS) is an effective weapon used by bacteria to outgrow or kill competitors. It can be used by endogenous commensal microbiota to prevent invasion by pathogens or by pathogens to overcome resident flora and successfully colonize a host or a specific environmental niche.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal