Nature Communications (Jun 2022)
Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor
- Xuanming Guo,
- Pallavi Asthana,
- Susma Gurung,
- Shuo Zhang,
- Sheung Kin Ken Wong,
- Samane Fallah,
- Chi Fung Willis Chow,
- Sijia Che,
- Lixiang Zhai,
- Zening Wang,
- Xin Ge,
- Zhixin Jiang,
- Jiayan Wu,
- Yijing Zhang,
- Xiaoyu Wu,
- Keyang Xu,
- Cheng Yuan Lin,
- Hiu Yee Kwan,
- Aiping Lyu,
- Zhongjun Zhou,
- Zhao-Xiang Bian,
- Hoi Leong Xavier Wong
Affiliations
- Xuanming Guo
- School of Chinese Medicine, Hong Kong Baptist University
- Pallavi Asthana
- School of Chinese Medicine, Hong Kong Baptist University
- Susma Gurung
- School of Chinese Medicine, Hong Kong Baptist University
- Shuo Zhang
- School of Biomedical Sciences, The University of Hong Kong
- Sheung Kin Ken Wong
- School of Biomedical Sciences, The University of Hong Kong
- Samane Fallah
- School of Chinese Medicine, Hong Kong Baptist University
- Chi Fung Willis Chow
- School of Chinese Medicine, Hong Kong Baptist University
- Sijia Che
- School of Chinese Medicine, Hong Kong Baptist University
- Lixiang Zhai
- School of Chinese Medicine, Hong Kong Baptist University
- Zening Wang
- Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Xin Ge
- Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Zhixin Jiang
- School of Biomedical Sciences, The University of Hong Kong
- Jiayan Wu
- School of Chinese Medicine, Hong Kong Baptist University
- Yijing Zhang
- School of Chinese Medicine, Hong Kong Baptist University
- Xiaoyu Wu
- Respiratory Department, Jinhua Guangfu hospital
- Keyang Xu
- School of Chinese Medicine, Hong Kong Baptist University
- Cheng Yuan Lin
- School of Chinese Medicine, Hong Kong Baptist University
- Hiu Yee Kwan
- School of Chinese Medicine, Hong Kong Baptist University
- Aiping Lyu
- School of Chinese Medicine, Hong Kong Baptist University
- Zhongjun Zhou
- School of Biomedical Sciences, The University of Hong Kong
- Zhao-Xiang Bian
- School of Chinese Medicine, Hong Kong Baptist University
- Hoi Leong Xavier Wong
- School of Chinese Medicine, Hong Kong Baptist University
- DOI
- https://doi.org/10.1038/s41467-022-31563-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 10
Abstract
Insulin sensitivity declines with age via unclear mechanisms. Here, the authors show that the activity of membrane type 1 matrix metalloproteinase (MT1-MMP) is increased with ageing, leading to cleavage of the insulin receptor, and show that metabolic effects can be rescued by MT1-MMP inhibition in mice.
