Ironing Out the Details: How Iron Orchestrates Macrophage Polarization

Yaoyao Xia; Yaoyao Xia; Yikun Li; Xiaoyan Wu; Qingzhuo Zhang; Siyuan Chen; Xianyong Ma; Xianyong Ma; Miao Yu; Miao Yu

doi:10.3389/fimmu.2021.669566

Frontiers in Immunology (May 2021)

Ironing Out the Details: How Iron Orchestrates Macrophage Polarization

Yaoyao Xia,
Yaoyao Xia,
Yikun Li,
Xiaoyan Wu,
Qingzhuo Zhang,
Siyuan Chen,
Xianyong Ma,
Xianyong Ma,
Miao Yu,
Miao Yu

Affiliations

Yaoyao Xia: State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and Evaluation, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China
Yaoyao Xia: College of Animal Science, South China Agricultural University, Guangzhou, China
Yikun Li: College of Animal Science, South China Agricultural University, Guangzhou, China
Xiaoyan Wu: College of Animal Science, South China Agricultural University, Guangzhou, China
Qingzhuo Zhang: College of Animal Science, South China Agricultural University, Guangzhou, China
Siyuan Chen: College of Animal Science, South China Agricultural University, Guangzhou, China
Xianyong Ma: State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and Evaluation, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China
Xianyong Ma: Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China
Miao Yu: State Key Laboratory of Livestock and Poultry Breeding, Key Laboratory of Animal Nutrition and Feed Science in South China, Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Animal Breeding and Nutrition, Guangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and Evaluation, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China
Miao Yu: Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China

DOI: https://doi.org/10.3389/fimmu.2021.669566
Journal volume & issue: Vol. 12

Abstract

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Iron fine-tunes innate immune responses, including macrophage inflammation. In this review, we summarize the current understanding about the iron in dictating macrophage polarization. Mechanistically, iron orchestrates macrophage polarization through several aspects, including cellular signaling, cellular metabolism, and epigenetic regulation. Therefore, iron modulates the development and progression of multiple macrophage-associated diseases, such as cancer, atherosclerosis, and liver diseases. Collectively, this review highlights the crucial role of iron for macrophage polarization, and indicates the potential application of iron supplementation as an adjuvant therapy in different inflammatory disorders relative to the balance of macrophage polarization.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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