Trans-illumination intestine projection imaging of intestinal motility in mice

Depeng Wang; Huijuan Zhang; Tri Vu; Ye Zhan; Akash Malhotra; Pei Wang; Upendra Chitgupi; Aliza Rai; Sizhe Zhang; Lidai Wang; Jan D. Huizinga; Jonathan F. Lovell; Jun Xia

doi:10.1038/s41467-021-21930-w

Nature Communications (Mar 2021)

Trans-illumination intestine projection imaging of intestinal motility in mice

Depeng Wang,
Huijuan Zhang,
Tri Vu,
Ye Zhan,
Akash Malhotra,
Pei Wang,
Upendra Chitgupi,
Aliza Rai,
Sizhe Zhang,
Lidai Wang,
Jan D. Huizinga,
Jonathan F. Lovell,
Jun Xia

Affiliations

Depeng Wang: Department of Biomedical Engineering, University at Buffalo, State University of New York
Huijuan Zhang: Department of Biomedical Engineering, University at Buffalo, State University of New York
Tri Vu: Department of Biomedical Engineering, University at Buffalo, State University of New York
Ye Zhan: Department of Biomedical Engineering, University at Buffalo, State University of New York
Akash Malhotra: Department of Mechanical and Biomedical Engineering, City University of Hong Kong
Pei Wang: Department of Mechanical and Biomedical Engineering, City University of Hong Kong
Upendra Chitgupi: Department of Biomedical Engineering, University at Buffalo, State University of New York
Aliza Rai: Department of Mechanical and Biomedical Engineering, City University of Hong Kong
Sizhe Zhang: Department of Biomedical Engineering, University at Buffalo, State University of New York
Lidai Wang: Department of Mechanical and Biomedical Engineering, City University of Hong Kong
Jan D. Huizinga: Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University
Jonathan F. Lovell: Department of Biomedical Engineering, University at Buffalo, State University of New York
Jun Xia: Department of Biomedical Engineering, University at Buffalo, State University of New York

DOI: https://doi.org/10.1038/s41467-021-21930-w
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

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Current preclinical imaging of intestine in animal models cannot reveal intestinal dynamics in awake condition. Here the authors report a Transillumination Intestine Projection (TIP) imaging system for free-moving mice, and showed the intestine dynamics in conscious animal in natural physiological states.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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