Nature Communications (Aug 2020)
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization
- Tzu-Han Lee,
- Chih-Fan Yeh,
- Ying-Tung Lee,
- Ying-Chun Shih,
- Yen-Ting Chen,
- Chen-Ting Hung,
- Ming-Yi You,
- Pei-Chen Wu,
- Tzu-Pin Shentu,
- Ru-Ting Huang,
- Yu-Shan Lin,
- Yueh-Feng Wu,
- Sung-Jan Lin,
- Frank-Leigh Lu,
- Po-Nien Tsao,
- Tzu-Hung Lin,
- Shen-Chuan Lo,
- Yi-Shuan Tseng,
- Wan-Lin Wu,
- Chiung-Nien Chen,
- Chau-Chung Wu,
- Shuei-Liong Lin,
- Anne I. Sperling,
- Robert D. Guzy,
- Yun Fang,
- Kai-Chien Yang
Affiliations
- Tzu-Han Lee
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Chih-Fan Yeh
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Ying-Tung Lee
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Ying-Chun Shih
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Yen-Ting Chen
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Chen-Ting Hung
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Ming-Yi You
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Pei-Chen Wu
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Tzu-Pin Shentu
- Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago
- Ru-Ting Huang
- Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago
- Yu-Shan Lin
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Yueh-Feng Wu
- Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University
- Sung-Jan Lin
- Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University
- Frank-Leigh Lu
- Department of Pediatrics, National Taiwan University Hospital
- Po-Nien Tsao
- Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University
- Tzu-Hung Lin
- Material and Chemical Research Laboratories, Industrial Technology Research Institute
- Shen-Chuan Lo
- Material and Chemical Research Laboratories, Industrial Technology Research Institute
- Yi-Shuan Tseng
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Wan-Lin Wu
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- Chiung-Nien Chen
- Department of Surgery, National Taiwan University Hospital
- Chau-Chung Wu
- Division of Cardiology, Department of Internal Medicine and Cardiovascular Center, National Taiwan University Hospital
- Shuei-Liong Lin
- Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University
- Anne I. Sperling
- Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago
- Robert D. Guzy
- Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago
- Yun Fang
- Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago
- Kai-Chien Yang
- Department and Graduate Institute of Pharmacology, National Taiwan University College of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-18047-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
Pulmonary fibrosis is a major public health problem with unclear mechanism and limited therapeutic options. Here the authors show that a fibroblast-enriched endoplasmic reticulum protein, TXNDC5, promotes pulmonary fibrosis by stabilizing TGFBR1 and show the potential of TXNDC5 as a therapeutic target against pulmonary fibrosis.
