The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States

Claire P. Smith; Rachel M. Hartman; Alexa M. Kugler; Verlena Little; Owen R. Baker; Tarayn A. Fairlie; Reinaldo E. Fernandez; Melissa B. Hagen; Elvira Honie; Oliver Laeyendecker; Claire M. Midgley; Dennie Parker; Marqia Sandoval; Saki Takahashi; Laura L. Hammitt; Catherine G. Sutcliffe

doi:10.3390/v16101573

Viruses (Oct 2024)

The Trajectory of Antibody Responses One Year Following SARS-CoV-2 Infection among Indigenous Individuals in the Southwest United States

Claire P. Smith,
Rachel M. Hartman,
Alexa M. Kugler,
Verlena Little,
Owen R. Baker,
Tarayn A. Fairlie,
Reinaldo E. Fernandez,
Melissa B. Hagen,
Elvira Honie,
Oliver Laeyendecker,
Claire M. Midgley,
Dennie Parker,
Marqia Sandoval,
Saki Takahashi,
Laura L. Hammitt,
Catherine G. Sutcliffe

Affiliations

Claire P. Smith: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Rachel M. Hartman: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Alexa M. Kugler: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Verlena Little: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Owen R. Baker: Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Tarayn A. Fairlie: Division of Coronaviruses and Other Respiratory Viruses, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Reinaldo E. Fernandez: Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
Melissa B. Hagen: Division of Coronaviruses and Other Respiratory Viruses, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Elvira Honie: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Oliver Laeyendecker: Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Claire M. Midgley: Division of Coronaviruses and Other Respiratory Viruses, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Dennie Parker: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Marqia Sandoval: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Saki Takahashi: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Laura L. Hammitt: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Catherine G. Sutcliffe: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA

DOI: https://doi.org/10.3390/v16101573
Journal volume & issue: Vol. 16, no. 10
p. 1573

Abstract

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SARS-CoV-2 antibody kinetics based on immunologic history is not fully understood. We analyzed anti-spike and anti-nucleocapsid antibody responses following acute infection in a cohort of Indigenous persons. The models of peak concentrations and decay rates estimated that one year after infection, participants would serorevert for anti-nucleocapsid antibodies and remain seropositive for anti-spike antibodies. The peak anti-spike concentrations were higher for individuals vaccinated prior to infection, but the decay rates were similar across immunologic status groups. Children had significantly lower peak anti-spike concentrations than adults. This study affirms the importance of continued vaccination to maintain high levels of immunity in the face of waning immunity.

Published in Viruses

ISSN: 1999-4915 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/viruses

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