HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

Andrew T. Jones; Xiaoying Shen; Korey L. Walter; Celia C. LaBranche; Linda S. Wyatt; Georgia D. Tomaras; David C. Montefiori; Bernard Moss; Dan H. Barouch; John D. Clements; Pamela A. Kozlowski; Raghavan Varadarajan; Rama Rao Amara

doi:10.1038/s41467-019-08739-4

Nature Communications (Feb 2019)

HIV-1 vaccination by needle-free oral injection induces strong mucosal immunity and protects against SHIV challenge

Andrew T. Jones,
Xiaoying Shen,
Korey L. Walter,
Celia C. LaBranche,
Linda S. Wyatt,
Georgia D. Tomaras,
David C. Montefiori,
Bernard Moss,
Dan H. Barouch,
John D. Clements,
Pamela A. Kozlowski,
Raghavan Varadarajan,
Rama Rao Amara

Affiliations

Andrew T. Jones: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University
Xiaoying Shen: Duke Human Vaccine Institute, Duke University Medical Center
Korey L. Walter: Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center
Celia C. LaBranche: Department of Surgery, Duke University Medical Center
Linda S. Wyatt: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Georgia D. Tomaras: Duke Human Vaccine Institute, Duke University Medical Center
David C. Montefiori: Department of Surgery, Duke University Medical Center
Bernard Moss: Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Dan H. Barouch: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School
John D. Clements: Department of Microbiology and Immunology, Tulane University School of Medicine
Pamela A. Kozlowski: Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center
Raghavan Varadarajan: Molecular Biophysics Unit, Indian Institute of Science
Rama Rao Amara: Emory Vaccine Center, Yerkes National Primate Research Center, Emory University

DOI: https://doi.org/10.1038/s41467-019-08739-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Oral vaccination is a potential option to elicit systemic and mucosal immunity against HIV. Here, Jones et al. show that oral vaccination with a modified needle-free injector induces protective immunity against SHIV in non-human primates and is superior to topical application of vaccines to oral tissues.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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