Frontiers in Microbiology (Nov 2022)
Pathogenicity and transmissibility studies on live attenuated duck enteritis virus vaccine in non-target species
- Jie Kong,
- Jie Kong,
- Jie Kong,
- Keyu Feng,
- Keyu Feng,
- Keyu Feng,
- Keyu Feng,
- Qiqi Zhao,
- Qiqi Zhao,
- Qiqi Zhao,
- Yazheng Chen,
- Yazheng Chen,
- Yazheng Chen,
- Jinfeng Wang,
- Jinfeng Wang,
- Jinfeng Wang,
- Sheng Chen,
- Sheng Chen,
- Sheng Chen,
- Guanming Shao,
- Guanming Shao,
- Guanming Shao,
- Liqin Liao,
- Liqin Liao,
- Liqin Liao,
- Yajuan Li,
- Yajuan Li,
- Yajuan Li,
- Zi Xie,
- Zi Xie,
- Zi Xie,
- Xinheng Zhang,
- Xinheng Zhang,
- Xinheng Zhang,
- Xinheng Zhang,
- Qingmei Xie,
- Qingmei Xie,
- Qingmei Xie,
- Qingmei Xie
Affiliations
- Jie Kong
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Jie Kong
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Jie Kong
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Keyu Feng
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Keyu Feng
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Keyu Feng
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Keyu Feng
- Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China
- Qiqi Zhao
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Qiqi Zhao
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Qiqi Zhao
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Yazheng Chen
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Yazheng Chen
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Yazheng Chen
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Jinfeng Wang
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Jinfeng Wang
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Jinfeng Wang
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Sheng Chen
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Sheng Chen
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Sheng Chen
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Guanming Shao
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Guanming Shao
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Guanming Shao
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Liqin Liao
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Liqin Liao
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Liqin Liao
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Yajuan Li
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Yajuan Li
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Yajuan Li
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Zi Xie
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Zi Xie
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Zi Xie
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Xinheng Zhang
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Xinheng Zhang
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Xinheng Zhang
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Xinheng Zhang
- Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China
- Qingmei Xie
- Guangdong Provincial Laboratory of Lingnan Modern Agricultural Science and Technology and Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science and Veterinary Medicine, South China Agricultural University, Guangzhou, China
- Qingmei Xie
- Guangdong Engineering Research Center for Vector Vaccine of Animal Virus, Guangzhou, China
- Qingmei Xie
- South China Collaborative Innovation Center for Poultry Disease Control and Product Safety, Guangzhou, China
- Qingmei Xie
- Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China
- DOI
- https://doi.org/10.3389/fmicb.2022.979368
- Journal volume & issue
-
Vol. 13
Abstract
In the second half of 2021, a highly pathogenic case occurred in a mixed chicken and duck family farm in Guangdong, China. After the duck flocks were immunized with live attenuated duck enteritis virus vaccine (live attenuated DEV vaccine), the chickens of the same farm showed clinical symptoms similar to duck enteritis, such as pericardial effusion, hepatic hemorrhagic spots, kidney enlargement, and intestinal bleeding, with mass mortality. The infection model of target animal tested, as well as the non-target species, was established according to the risk of live attenuated DEV vaccine and transmission in chickens. Live attenuated DEV vaccine was initially replicated in host animals, released the virus, and effectively colonized in the common environment, according to birds challenged experiments. There was evidence to suggest the mode of transmission of duck enteritis virus, and horizontal transmission is the main route of DEV transmission. In addition, high levels of virus titer were detected in chicken embryos and different tissues of SPF chickens. Different degrees of pathological damage occurred in the tissue of chickens. After the SPF chickens were inoculated with live attenuated DEV vaccine, different degrees of virulence were exhibited, pointing to a potential risk to other domestic bird species.
Keywords
- live attenuated duck enteritis virus vaccine
- duck enteritis virus
- poultry public health
- viral transmission
- biosafety risks
