Nature Communications (Jan 2021)
Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia
- Wei-Yu Lin,
- Sarah E. Fordham,
- Nicola Sunter,
- Claire Elstob,
- Thahira Rahman,
- Elaine Willmore,
- Colin Shepherd,
- Gordon Strathdee,
- Tryfonia Mainou-Fowler,
- Rachel Piddock,
- Hannah Mearns,
- Timothy Barrow,
- Richard S. Houlston,
- Helen Marr,
- Jonathan Wallis,
- Geoffrey Summerfield,
- Scott Marshall,
- Andrew Pettitt,
- Christopher Pepper,
- Christopher Fegan,
- Francesco Forconi,
- Martin J. S. Dyer,
- Sandrine Jayne,
- April Sellors,
- Anna Schuh,
- Pauline Robbe,
- David Oscier,
- James Bailey,
- Syed Rais,
- Alison Bentley,
- Lynn Cawkwell,
- Paul Evans,
- Peter Hillmen,
- Guy Pratt,
- David J. Allsup,
- James M. Allan
Affiliations
- Wei-Yu Lin
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Sarah E. Fordham
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Nicola Sunter
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Claire Elstob
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Thahira Rahman
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Elaine Willmore
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Colin Shepherd
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Gordon Strathdee
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Tryfonia Mainou-Fowler
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Rachel Piddock
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Hannah Mearns
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- Timothy Barrow
- Faculty of Health Sciences and Wellbeing, University of Sunderland
- Richard S. Houlston
- Division of Genetics and Epidemiology, The Institute of Cancer Research
- Helen Marr
- Department of Haematology, Freeman Hospital
- Jonathan Wallis
- Department of Haematology, Freeman Hospital
- Geoffrey Summerfield
- Queen Elizabeth Hospital
- Scott Marshall
- City Hospitals Sunderland NHS Trust
- Andrew Pettitt
- University of Liverpool
- Christopher Pepper
- Brighton and Sussex Medical School, University of Sussex
- Christopher Fegan
- Institute of Cancer and Genetics, School of Medicine, Cardiff University
- Francesco Forconi
- Cancer Sciences Unit, Cancer Research UK and NIHR Experimental Cancer Medicine Centres, University of Southampton
- Martin J. S. Dyer
- The Ernest and Helen Scott Haematological Research Institute, Leicester Cancer Research Centre, University of Leicester
- Sandrine Jayne
- The Ernest and Helen Scott Haematological Research Institute, Leicester Cancer Research Centre, University of Leicester
- April Sellors
- The Ernest and Helen Scott Haematological Research Institute, Leicester Cancer Research Centre, University of Leicester
- Anna Schuh
- University of Oxford
- Pauline Robbe
- University of Oxford
- David Oscier
- Royal Bournemouth Hospital
- James Bailey
- Hull University Teaching Hospital NHS Trust
- Syed Rais
- Hull University Teaching Hospital NHS Trust
- Alison Bentley
- Centre for Atherothrombosis and Metabolic Disease, Hull York Medical School
- Lynn Cawkwell
- University of Hull
- Paul Evans
- Haematological Malignancy Diagnostic Service Laboratory, St James’ Institute of Oncology
- Peter Hillmen
- Section of Experimental Haematology, Leeds Institute of Medical Research at St James’s, University of Leeds
- Guy Pratt
- University of Birmingham
- David J. Allsup
- Hull University Teaching Hospital NHS Trust
- James M. Allan
- Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University
- DOI
- https://doi.org/10.1038/s41467-020-20822-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 8
Abstract
The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with progressive disease.
