Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya

Ching-Jie Lin; I-Wen Lo; Yu-Chi Lin; Shun-Ying Chen; Ching-Te Chien; Yao-Haur Kuo; Tsong-Long Hwang; Shorong-Shii Liou; Ya-Ching Shen

doi:10.3390/molecules21091167

Molecules (Sep 2016)

Tetranortriterpenes and Limonoids from the Roots of Aphanamixis polystachya

Ching-Jie Lin,
I-Wen Lo,
Yu-Chi Lin,
Shun-Ying Chen,
Ching-Te Chien,
Yao-Haur Kuo,
Tsong-Long Hwang,
Shorong-Shii Liou,
Ya-Ching Shen

Affiliations

Ching-Jie Lin: School of Pharmacy, College of Medicine, National Taiwan University, No. 33, Linsen S. Rd., Zhongzheng Dist., Taipei 10050, Taiwan
I-Wen Lo: School of Pharmacy, College of Medicine, National Taiwan University, No. 33, Linsen S. Rd., Zhongzheng Dist., Taipei 10050, Taiwan
Yu-Chi Lin: Department of Life Sciences, National Cheng Kung University, No. 1, University Road, Tainan 701, Taiwan
Shun-Ying Chen: Taiwan Forestry Research Institute, Council of Agriculture, Executive Yuan, No. 53, Nanhai Rd., Zhongzheng Dist., Taipei 10066, Taiwan
Ching-Te Chien: Taiwan Forestry Research Institute, Council of Agriculture, Executive Yuan, No. 53, Nanhai Rd., Zhongzheng Dist., Taipei 10066, Taiwan
Yao-Haur Kuo: National Research Institute of Chinese Medicine, Ministry of Health and Welfare, No. 155-1, Sec. 2, Linong St., Beitou District, Taipei 11221, Taiwan
Tsong-Long Hwang: Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan
Shorong-Shii Liou: Department of Pharmacy, Tajen University, No. 20, Weixin Rd., Yanpu Township, Pingtung 90741, Taiwan
Ya-Ching Shen: School of Pharmacy, College of Medicine, National Taiwan University, No. 33, Linsen S. Rd., Zhongzheng Dist., Taipei 10050, Taiwan

DOI: https://doi.org/10.3390/molecules21091167
Journal volume & issue: Vol. 21, no. 9
p. 1167

Abstract

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Phytochemical investigation of the acetone extract from the roots of Aphanamixis polystachya resulted in isolation of four new tetranortriterpenes (1–4) in addition to one protolimonoid (methyl-1ξ,7R-diacetoxy-23R,25-dihydroxy-20S,24R-21,24-epoxy-3,4-seco-apotirucall-4(28),14(15)-diene-3-oate (5)), five known limonoids (rohituka 3 (6), rohituka 7 (7), nymania 1 (8), rubrin G (9), prieurianin (10)) and a steroid (2,3-dihydroxy-5-pregnan-16-one (11)). Their structures were determined by spectroscopic analyses, including 2D-NMR (COSY, HMQC, HMBC, and NOESY) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Cytotoxic and anti-inflammatory activities of these compounds were evaluated. Compounds 4 and 5 showed significant inhibition against superoxide generation and elastase release by human neutrophils in response to (formyl-l-methionyl-l-leucyl-l-phenylalanine/cytochalasin B) (FMLP/CB).

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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